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Study · Randomized controlled trial · n = 73 · 2021

2 results

Craving Moderates the Effects of Intranasal Oxytocin on Anger in Response to Social Stress Among Veterans With Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder.

Melkonian AJ, Flanagan JC, Calhoun CD, Hogan JN, Back SE

Journal of clinical psychopharmacology1 Jul 2021Cited by 6 (Europe PMC)

PMID34121063 (opens in a new tab)PMCIDPMC12869547 (opens in a new tab)DOI10.1097/jcp.0000000000001434 (opens in a new tab)PepBankPUB-34121063
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In veterans with PTSD and alcohol use disorder, a marginally significant interaction showed a positive association between baseline craving and post-stress anger in the oxytocin group.

    In plain wordsIn veterans with PTSD and alcohol use disorder, anger after stress rose with baseline craving in the oxytocin group.

    Peptide
    Oxytocin
    Outcome
    IncreasePost-TSST anger: interaction of baseline craving and oxytocin
    Study

    n = 73

    Comparator
    Placebo (saline)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    A marginally significant interaction was observed, suggesting a positive association between baseline craving and anger for those in the oxytocin group (B = 0.65, P = 0.01).
    2 context sentences
    Summary · context
    We examined the influence of intranasally administered oxytocin on connections between alcohol craving and stress-induced anger in a sample of 73 veterans (91.3% men) with co-occurring PTSD and AUD.
    Summary · context
    Participants self-administered oxytocin (40 IU) or placebo (saline) 45 minutes before completing the Trier Social Stress Task (TSST).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In veterans with PTSD and alcohol use disorder who reported low craving, intranasal oxytocin lowered post-stress anger compared with placebo.

    In plain wordsIn veterans with PTSD and alcohol use disorder and low craving, oxytocin lowered anger after stress more than placebo.

    Peptide
    Oxytocin
    Outcome
    DecreasePost-TSST anger in participants with low baseline craving
    Study

    n = 73

    Comparator
    Placebo (saline)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Among those reporting low craving, participants in the oxytocin group reported significantly lower post-TSST anger than those in the placebo group.
    2 context sentences
    Summary · context
    We examined the influence of intranasally administered oxytocin on connections between alcohol craving and stress-induced anger in a sample of 73 veterans (91.3% men) with co-occurring PTSD and AUD.
    Summary · context
    Participants self-administered oxytocin (40 IU) or placebo (saline) 45 minutes before completing the Trier Social Stress Task (TSST).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1Results postedNCT02058251

Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress

Medical University of South Carolinan = 73Feb 2014 to Apr 2017

Alcohol Use Disorders

Trial pageClinicalTrials.govUpdated 14 Mar 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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