(Re-)activity in the caregiving situation: Genetic diversity within Oxytocin-Vasopressin Pathway is associated with salivary oxytocin and vasopressin concentrations in response to contact with a crying infant-simulator.

Rybicka M, Kaźmierczak M, Pawlicka P, Łada-Maśko AB, Anikiej-Wiczenbach P, Bielawski KP

Psychoneuroendocrinology1 Jun 2021Cited by 6 (Europe PMC)

PMID34102428DOI10.1016/j.psyneuen.2021.105294PepBankPUB-34102428

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyMechanism
In adult couples caring for an infant simulator, the OXTR SNPs rs53576 and rs2254298 had no or a minor impact on salivary oxytocin levels.
In plain wordsIn adult couples, the two best-known oxytocin receptor gene variants had little or no link to the body's own oxytocin levels in saliva.
Peptide
Oxytocin
Outcome
No significant changeSalivary OT and OXTR rs53576 and rs2254298
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The two most frequently studied OXTR SNPs (rs53576 and rs2254298) had no or a minor impact on higher OT levels
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this reported observational study was to examine the impact of genetic variations within genes related to OT and AVP signaling pathway on hormones levels' changes in response to the caregiving situation.
Summary · context
A total of 221 adult intimate couples (110 childless, non-pregnant and 111 expectant couples) participated in three 10 min sessions, during which they were taking care of a crying life-like simulator.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3410242801
02HumanEndogenous levelObservational studyMechanism
In adult couples caring for an infant simulator, higher salivary oxytocin levels were linked to the rs1042778, rs13316193, rs2228485, rs2268490 and rs4686302 genotypes.
In plain wordsIn adult couples, higher levels of the body's own oxytocin in saliva were linked to certain gene variants.
Peptide
Oxytocin
Outcome
Not applicableSalivary OT and genotypes rs1042778, rs13316193, rs2228485, rs2268490, rs4686302
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
which were linked to rs1042778, rs13316193, rs2228485, rs2268490, rs4686302 genotypes.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this reported observational study was to examine the impact of genetic variations within genes related to OT and AVP signaling pathway on hormones levels' changes in response to the caregiving situation.
Summary · context
A total of 221 adult intimate couples (110 childless, non-pregnant and 111 expectant couples) participated in three 10 min sessions, during which they were taking care of a crying life-like simulator.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3410242802
03HumanEndogenous levelObservational studyMechanism
In adult couples caring for an infant simulator, salivary oxytocin levels varied with the OT (rs2770378, rs4813625), CD38 (rs379686) and 5-HTR2A (rs6314) genotypes.
In plain wordsIn adult couples, the body's own oxytocin levels in saliva varied with certain variants of the OT, CD38 and 5-HTR2A genes.
Peptide
Oxytocin
Outcome
Not applicableSalivary OT and OT, CD38 and 5-HTR2A genotypes
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
OT levels varied depending on the OT (rs2770378, rs4813625), CD38 (rs379686), and 5-HTR2A (rs6314) genotype.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this reported observational study was to examine the impact of genetic variations within genes related to OT and AVP signaling pathway on hormones levels' changes in response to the caregiving situation.
Summary · context
A total of 221 adult intimate couples (110 childless, non-pregnant and 111 expectant couples) participated in three 10 min sessions, during which they were taking care of a crying life-like simulator.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3410242803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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