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Study · Animal study (in vivo) · rat · 2021

5 results

[The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain].

Dergunova LV, Dmitrieva VG, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Valieva LV, Sudarkina OY, Gubsky LV, Myasoedov NF, Limborska SA

Molekuliarnaia biologiia1 May 2021Cited by 7 (Europe PMC)

PMID34097675 (opens in a new tab)DOI10.31857/s0026898421010043 (opens in a new tab)PepBankPUB-34097675
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with transient brain ischemia-reperfusion, Semax statistically significantly decreased Il1a mRNA, offsetting the rise induced by ischemia-reperfusion.

    In plain wordsIn rats with brain ischemia, Semax lowered the activity of the inflammation gene Il1a that ischemia had raised.

    Peptide
    Semax
    Outcome
    DecreaseIl1a mRNA level
    Study

    ratn: not reported in source

    Transient middle cerebral artery occlusion (ischemia-reperfusion)
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    exposure to Semax leads to a statistically significant decrease in the Il1a, Il1b, Il6, Ccl3, and Cxcl2 mRNAs
    1 context sentence
    Summary · context
    Our earlier RNA-Seq analysis of the transcriptome in an ischemic model of transient occlusion of the middle cerebral artery showed an increase in the mRNA levels of many proinflammatory genes, and the suppression of their induction by Semax.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with transient brain ischemia-reperfusion, Semax statistically significantly decreased Il1b mRNA, offsetting the rise induced by ischemia-reperfusion.

    In plain wordsIn rats with brain ischemia, Semax lowered the activity of the inflammation gene Il1b that ischemia had raised.

    Peptide
    Semax
    Outcome
    DecreaseIl1b mRNA level
    Study

    ratn: not reported in source

    Transient middle cerebral artery occlusion (ischemia-reperfusion)
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    exposure to Semax leads to a statistically significant decrease in the Il1a, Il1b, Il6, Ccl3, and Cxcl2 mRNAs
    1 context sentence
    Summary · context
    Our earlier RNA-Seq analysis of the transcriptome in an ischemic model of transient occlusion of the middle cerebral artery showed an increase in the mRNA levels of many proinflammatory genes, and the suppression of their induction by Semax.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with transient brain ischemia-reperfusion, Semax statistically significantly decreased Il6 mRNA, offsetting the rise induced by ischemia-reperfusion.

    In plain wordsIn rats with brain ischemia, Semax lowered the activity of the inflammation gene Il6 that ischemia had raised.

    Peptide
    Semax
    Outcome
    DecreaseIl6 mRNA level
    Study

    ratn: not reported in source

    Transient middle cerebral artery occlusion (ischemia-reperfusion)
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    exposure to Semax leads to a statistically significant decrease in the Il1a, Il1b, Il6, Ccl3, and Cxcl2 mRNAs
    1 context sentence
    Summary · context
    Our earlier RNA-Seq analysis of the transcriptome in an ischemic model of transient occlusion of the middle cerebral artery showed an increase in the mRNA levels of many proinflammatory genes, and the suppression of their induction by Semax.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with transient brain ischemia-reperfusion, Semax statistically significantly decreased Ccl3 mRNA, offsetting the rise induced by ischemia-reperfusion.

    In plain wordsIn rats with brain ischemia, Semax lowered the activity of the inflammation gene Ccl3 that ischemia had raised.

    Peptide
    Semax
    Outcome
    DecreaseCcl3 mRNA level
    Study

    ratn: not reported in source

    Transient middle cerebral artery occlusion (ischemia-reperfusion)
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    exposure to Semax leads to a statistically significant decrease in the Il1a, Il1b, Il6, Ccl3, and Cxcl2 mRNAs
    1 context sentence
    Summary · context
    Our earlier RNA-Seq analysis of the transcriptome in an ischemic model of transient occlusion of the middle cerebral artery showed an increase in the mRNA levels of many proinflammatory genes, and the suppression of their induction by Semax.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with transient brain ischemia-reperfusion, Semax statistically significantly decreased Cxcl2 mRNA, offsetting the rise induced by ischemia-reperfusion.

    In plain wordsIn rats with brain ischemia, Semax lowered the activity of the inflammation gene Cxcl2 that ischemia had raised.

    Peptide
    Semax
    Outcome
    DecreaseCxcl2 mRNA level
    Study

    ratn: not reported in source

    Transient middle cerebral artery occlusion (ischemia-reperfusion)
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    exposure to Semax leads to a statistically significant decrease in the Il1a, Il1b, Il6, Ccl3, and Cxcl2 mRNAs
    1 context sentence
    Summary · context
    Our earlier RNA-Seq analysis of the transcriptome in an ischemic model of transient occlusion of the middle cerebral artery showed an increase in the mRNA levels of many proinflammatory genes, and the suppression of their induction by Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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