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Study · Randomized controlled trial · 2021

3 results

Polyethylene glycol combined with linaclotide is an effective and well-tolerated bowel preparation regimen for colonoscopy: an endoscopist-blinded, randomized, controlled trial.

Zhang M, Zou W, Xu C, Jia R, Liu K, Xu Q, Xu H

European journal of gastroenterology & hepatology1 Dec 2021Cited by 24 (Europe PMC)

PMID34034273 (opens in a new tab)DOI10.1097/meg.0000000000002184 (opens in a new tab)PepBankPUB-34034273
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, adding linaclotide to 2 L PEG increased adequate preparation to 87.9% versus 77.0% (P = 0.017).

    In plain wordsIn colonoscopy patients, adding linaclotide to 2 L PEG increased adequate bowel preparation compared with 2 L PEG alone.

    Peptide
    Linaclotide
    Outcome
    IncreaseAdequate bowel preparation
    Study

    n: not reported in source

    Comparator
    2 L PEG alone
    Analysis
    Primary
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    290 µgAs given in this study (human).

    Measurements

    Adequate bowel preparation
    87.9%
    2 L PEG + 290 µg linaclotide
    Adequate bowel preparation
    77%
    2 L PEG alone

    Source sentences

    Summary
    The percentage of adequate bowel preparation in the 2 L PEG + L group was higher than that of the 2 L PEG group (87.9% vs. 77.0%; P = 0.017)
    1 context sentence
    Summary · context
    This was an endoscopist-blinded, randomized, controlled trial of 432 patients randomly assigned to three groups: 2 L PEG, 4 L PEG and 2 L PEG + 290 µg linaclotide (2 L PEG + L group).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, 2 L PEG plus linaclotide improved total and segmental BBPS scores versus 2 L PEG alone.

    In plain wordsIn colonoscopy patients, adding linaclotide improved total and segmental bowel cleansing scores compared with 2 L PEG alone.

    Peptide
    Linaclotide
    Outcome
    Direction not reportedTotal and segmental BBPS scores
    Study

    n: not reported in source

    Comparator
    2 L PEG alone
    Analysis
    Primary
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    290 µgAs given in this study (human).

    Source sentences

    Summary
    In terms of the mean (SD) BBPS score for the total and segmental colons, the bowel cleansing efficacy of 2 L PEG + L was superior to that of 2 L PEG and similar to that of 4 L PEG.
    1 context sentence
    Summary · context
    This was an endoscopist-blinded, randomized, controlled trial of 432 patients randomly assigned to three groups: 2 L PEG, 4 L PEG and 2 L PEG + 290 µg linaclotide (2 L PEG + L group).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, tolerance, including complications, willingness to repeat and sleeping quality, was similar with 2 L PEG plus linaclotide and 2 L PEG alone.

    In plain wordsIn colonoscopy patients, complications, willingness to repeat and sleep quality were similar with 2 L PEG plus linaclotide and 2 L PEG alone.

    Peptide
    Linaclotide
    Outcome
    No significant changePatient tolerance
    Study

    n: not reported in source

    Comparator
    2 L PEG alone
    Analysis
    Secondary
    Outcome group
    Treatment Tolerability · Gastrointestinal
    Studied dose
    290 µgAs given in this study (human).

    Source sentences

    Summary
    Patient's tolerance (including complications, willingness to repeat and sleeping quality) were compatible between the 2 L and 2 L + L group, and the 4 L group was the worst among these three groups.
    1 context sentence
    Summary · context
    This was an endoscopist-blinded, randomized, controlled trial of 432 patients randomly assigned to three groups: 2 L PEG, 4 L PEG and 2 L PEG + 290 µg linaclotide (2 L PEG + L group).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT05291325

Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy

Changhai Hospitaln = 1,60725 May 2022 to 28 Apr 2024

Bowel Preparation for Colonoscopy

Trial pageClinicalTrials.govUpdated 20 Jun 2024

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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