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Study · Animal study (in vivo) · rat · 2021

11 results

Pretreatment with mechano growth factor E peptide attenuates osteoarthritis through improving cell proliferation and extracellular matrix synthesis in chondrocytes under severe hypoxia.

Sha Y, Cai W, Mohanad Khalid A, Chi Q, Wang J, Sun T, Wang C

International immunopharmacology18 May 2021Cited by 8 (Europe PMC)

PMID34015701 (opens in a new tab)DOI10.1016/j.intimp.2021.107628 (opens in a new tab)PepBankPUB-34015701
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of MIA-induced osteoarthritis, MGF E peptide reduced the progression of osteoarthritis by retarding cartilage degeneration after 4 or 6 weeks.

    In plain wordsIn rats with induced osteoarthritis, MGF E peptide slowed cartilage breakdown.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseCartilage degeneration in MIA-induced osteoarthritis
    Study

    ratn: not reported in source

    Rat monosodium iodoacetate (MIA) osteoarthritis model
    Comparator
    MIA-induced osteoarthritis without MGF E peptide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF E peptide also reduced the progression of MIA-induced OA by retarding cartilage degeneration, upregulating type II collagen synthesis, and improving ECM distribution after 4 or 6 weeks.
    2 context sentences
    Summary · context
    In a rat model of monosodium iodoacetate (MIA)-induced OA.
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of MIA-induced osteoarthritis, MGF E peptide upregulated type II collagen synthesis after 4 or 6 weeks.

    In plain wordsIn rats with induced osteoarthritis, MGF E peptide increased type II collagen production.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseType II collagen synthesis in MIA-induced osteoarthritis
    Study

    ratn: not reported in source

    Rat monosodium iodoacetate (MIA) osteoarthritis model
    Comparator
    MIA-induced osteoarthritis without MGF E peptide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF E peptide also reduced the progression of MIA-induced OA by retarding cartilage degeneration, upregulating type II collagen synthesis, and improving ECM distribution after 4 or 6 weeks.
    2 context sentences
    Summary · context
    In a rat model of monosodium iodoacetate (MIA)-induced OA.
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of MIA-induced osteoarthritis, MGF E peptide improved extracellular matrix distribution after 4 or 6 weeks.

    In plain wordsIn rats with induced osteoarthritis, MGF E peptide improved how the cartilage matrix was arranged.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseExtracellular matrix distribution in MIA-induced osteoarthritis
    Study

    ratn: not reported in source

    Rat monosodium iodoacetate (MIA) osteoarthritis model
    Comparator
    MIA-induced osteoarthritis without MGF E peptide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF E peptide also reduced the progression of MIA-induced OA by retarding cartilage degeneration, upregulating type II collagen synthesis, and improving ECM distribution after 4 or 6 weeks.
    2 context sentences
    Summary · context
    In a rat model of monosodium iodoacetate (MIA)-induced OA.
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  4. 04LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the loss of cell viability.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced the loss of cell viability.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseChondrocyte viability under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    cell viability, cell proliferation, and type II collagen expression in chondrocytes were significantly inhibited
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  5. 05LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the loss of cell proliferation.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced the loss of cell growth.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseChondrocyte proliferation under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    cell viability, cell proliferation, and type II collagen expression in chondrocytes were significantly inhibited
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  6. 06LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the loss of type II collagen expression.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced the loss of type II collagen.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseType II collagen expression under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    cell viability, cell proliferation, and type II collagen expression in chondrocytes were significantly inhibited
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  7. 07LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the increase in cell apoptosis.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced cell death.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseChondrocyte apoptosis under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    whereas cell apoptosis and expression levels of hypoxia inducible factor 1 alpha, type I collagen, and matrix metalloproteinases 1/13 were clearly induced
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  8. 08LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the induced expression of hypoxia inducible factor 1 alpha.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced a low-oxygen stress signal.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseHypoxia inducible factor 1 alpha expression under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    whereas cell apoptosis and expression levels of hypoxia inducible factor 1 alpha, type I collagen, and matrix metalloproteinases 1/13 were clearly induced
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  9. 09LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the induced expression of type I collagen.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced the rise in type I collagen expression.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseType I collagen expression under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    whereas cell apoptosis and expression levels of hypoxia inducible factor 1 alpha, type I collagen, and matrix metalloproteinases 1/13 were clearly induced
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  10. 10LabIn vitro (cells)Efficacy outcome

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide reduced the induced expression of matrix metalloproteinases 1/13.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment reduced enzymes that break down cartilage.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMatrix metalloproteinase 1/13 expression under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with MGF E peptide reduced the abovementioned adverse effects induced by CoCl2-simulated severe hypoxia in chondrocytes.
    2 context sentences
    Summary · context
    whereas cell apoptosis and expression levels of hypoxia inducible factor 1 alpha, type I collagen, and matrix metalloproteinases 1/13 were clearly induced
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.
  11. 11LabIn vitro (cells)Mechanism

    In chondrocytes under simulated severe hypoxia, pretreatment with MGF E peptide upregulated proliferation through the PI3K-Akt and MEK-ERK1/2 signaling pathways.

    In plain wordsIn cartilage cells under low oxygen, MGF E peptide pretreatment increased cell growth through the PI3K-Akt and MEK-ERK1/2 pathways.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseChondrocyte proliferation signaling pathways under severe hypoxia
    Study

    n: not reported in source

    Chondrocytes with CoCl2-simulated severe hypoxia
    Comparator
    CoCl2-simulated severe hypoxia without pretreatment
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment also upregulated the proliferation of chondrocytes under severe hypoxia through the PI3K-Akt and MEK-ERK1/2 signaling pathways.
    1 context sentence
    Summary · context
    In this study, the effects of severe hypoxia and treatment with mechano growth factor (MGF) E peptide on metabolism of the extracellular matrix (ECM) during the progression of OA were determined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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