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Study · Measured the body's own peptide · 2021

2 results

Structural differences of neutrophil extracellular traps induced by biochemical and microbiologic stimuli under healthy and autoimmune milieus.

Sosa-Luis SA, Ríos-Ríos WJ, Gómez-Bustamante ÁE, Romero-Tlalolini MLÁ, Aguilar-Ruiz SR, Aguilar-Ruiz SR, Baltierez-Hoyos R, Torres-Aguilar H

Immunologic research8 May 2021Cited by 4 (Europe PMC)

PMID33966252 (opens in a new tab)DOI10.1007/s12026-021-09199-z (opens in a new tab)PepBankPUB-33966252
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueMechanism

    NET composition of DNA and the body's own LL37 differed between biochemical and microbial stimuli despite similar NET morphology.

    In plain wordsIn lab tests, the amount of the body's own LL37 in neutrophil traps differed depending on what triggered them.

    Peptide
    LL-37
    Outcome
    MixedLL37 content of NETs by inducing stimulus
    Study

    n: not reported in source

    Neutrophil extracellular traps with healthy or SLE plasma
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The results showed a differential composition of DNA and the antimicrobial peptide cathelicidin (LL37) and a variable enzymatic activity (neutrophil elastase, cathepsin G, myeloperoxidase) induced by the different stimuli despite showing morphologically similar NETs.
    1 context sentence
    Summary · context
    to evaluate structural and enzymatic divergences in NET composition induced by biochemical (phorbol myristate acetate [PMA] and hypochlorous acid [HOCl]) and microbiologic (Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa) stimuli, along with the presence of plasma from healthy do…

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueMechanism

    SLE plasma increased release of DNA and the body's own LL37 during NET induction, independent of the trigger stimulus.

    In plain wordsIn lab tests, lupus plasma raised the release of the body's own LL37 from neutrophils compared with healthy plasma.

    Peptide
    LL-37
    Outcome
    IncreaseLL37 release during NET induction with SLE plasma
    Study

    n: not reported in source

    Neutrophil extracellular traps with healthy or SLE plasma
    Comparator
    Plasma from healthy donors
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Additionally, SLE plasma´s presence increased DNA and LL37 release during NET induction independently of the trigger stimulus but with no enzymatic activity differences.
    1 context sentence
    Summary · context
    to evaluate structural and enzymatic divergences in NET composition induced by biochemical (phorbol myristate acetate [PMA] and hypochlorous acid [HOCl]) and microbiologic (Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa) stimuli, along with the presence of plasma from healthy do…

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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