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Study · Animal study (in vivo) · 2021

2 results

Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages.

Dong L, Tan CW, Feng PJ, Liu FB, Liu DX, Zhou JJ, Chen Y, Yang XX, Zhu YH, Zhu ZQ

Molecular immunology3 May 2021Cited by 17 (Europe PMC)

PMID33957479 (opens in a new tab)DOI10.1016/j.molimm.2021.04.023 (opens in a new tab)PepBankPUB-33957479
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In vivo, LR12 blockade of TREM-1 ameliorated LPS-induced endoplasmic reticulum stress.

    In plain wordsIn animals, LR12 reduced endoplasmic reticulum stress induced by LPS.

    Peptide
    Nangibotide
    Outcome
    DecreaseEndoplasmic reticulum stress
    Study

    n: not reported in source

    LPS-induced endoplasmic reticulum stress
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, we found that blockade of TREM-1 with LR12 ameliorated ER stress induced by LPS in vitro and in vivo.
    1 context sentence
    Title · context
    Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages.
  2. 02LabIn vitro (cells)Mechanism

    In vitro, LR12 blockade of TREM-1 ameliorated LPS-induced endoplasmic reticulum stress.

    In plain wordsIn cells, LR12 reduced endoplasmic reticulum stress induced by LPS.

    Peptide
    Nangibotide
    Outcome
    DecreaseEndoplasmic reticulum stress
    Study

    mousen: not reported in source

    LPS-exposed macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, we found that blockade of TREM-1 with LR12 ameliorated ER stress induced by LPS in vitro and in vivo.
    1 context sentence
    Title · context
    Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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