Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice.

Brent MB, Stoltenborg FE, Brüel A, Thomsen JS

Frontiers in endocrinology19 Apr 2021Cited by 19 (Europe PMC)

PMID33953694PMCIDPMC8092394DOI10.3389/fendo.2021.628994PepBankPUB-33953694

Summary

Three bone anabolic pharmaceuticals are currently approved for treatment of osteoporosis, teriparatide (PTH (1-34)), the parathyroid hormone-related protein analog abaloparatide (ABL), and romosozumab. The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice. Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12). The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks. To assess the effect of PTH and ABL, the hindlimb bones were analyzed with DXA, µCT, mechanical testing, dynamic bone histomorphometry, and histological quantification of bone cells. In addition, serum calcium concentration was determined. PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl. In addition, ABL also significantly increased mid-diaphyseal cortical thickness and bone area compared to Ctrl. Neither PTH nor ABL significantly increased bone strength at the femoral neck. In conclusion, abaloparatide and PTH have similar bone anabolic properties when compared directly mole-to-mole in mice.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide significantly increased femoral areal BMD versus saline control.
In plain wordsIn mice, abaloparatide increased femoral bone density versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseFemoral areal BMD
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369401
02AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide increased femoral areal BMD with borderline significance versus saline control, with p = 0.06.
In plain wordsIn mice, teriparatide increased femoral bone density with borderline significance versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeFemoral areal BMD
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369402
03AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased femoral mid-diaphyseal bone strength versus saline control.
In plain wordsIn mice, abaloparatide increased femoral mid-diaphyseal bone strength versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseFemoral mid-diaphyseal bone strength
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369403
04AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide increased femoral mid-diaphyseal bone strength versus saline control.
In plain wordsIn mice, teriparatide increased femoral mid-diaphyseal bone strength versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral mid-diaphyseal bone strength
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369404
05AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased femoral metaphyseal, epiphyseal, and vertebral bone volume fraction versus saline control.
In plain wordsIn mice, abaloparatide increased bone volume fraction in the femur and vertebrae versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseBone volume fraction
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369405
06AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide increased femoral metaphyseal, epiphyseal, and vertebral bone volume fraction versus saline control.
In plain wordsIn mice, teriparatide increased bone volume fraction in the femur and vertebrae versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone volume fraction
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369406
07AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased bone connectivity density versus saline control.
In plain wordsIn mice, abaloparatide increased bone connectivity density versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseConnectivity density
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369407
08AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide increased bone connectivity density versus saline control.
In plain wordsIn mice, teriparatide increased bone connectivity density versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseConnectivity density
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369408
09AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased volumetric BMD versus saline control.
In plain wordsIn mice, abaloparatide increased volumetric bone density versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseVolumetric BMD
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369409
10AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide increased volumetric BMD versus saline control.
In plain wordsIn mice, teriparatide increased volumetric bone density versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseVolumetric BMD
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369410
11AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased bone formation rate versus saline control.
In plain wordsIn mice, abaloparatide increased bone formation rate versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseBone formation rate
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369411
12AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide increased bone formation rate versus saline control.
In plain wordsIn mice, teriparatide increased bone formation rate versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation rate
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369412
13AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased mid-diaphyseal cortical thickness versus saline control.
In plain wordsIn mice, abaloparatide increased mid-diaphyseal cortical thickness versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseMid-diaphyseal cortical thickness
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
In addition, ABL also significantly increased mid-diaphyseal cortical thickness and bone area compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369413
14AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide increased mid-diaphyseal bone area versus saline control.
In plain wordsIn mice, abaloparatide increased mid-diaphyseal bone area versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseMid-diaphyseal bone area
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
In addition, ABL also significantly increased mid-diaphyseal cortical thickness and bone area compared to Ctrl.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369414
15AnimalAnimal study (in vivo)Efficacy outcome
In female mice, abaloparatide did not significantly increase femoral neck bone strength versus saline control.
In plain wordsIn mice, abaloparatide did not significantly increase femoral neck bone strength versus saline control.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeFemoral neck bone strength
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
96 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
Neither PTH nor ABL significantly increased bone strength at the femoral neck.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369415
16AnimalAnimal study (in vivo)Efficacy outcome
In female mice, teriparatide did not significantly increase femoral neck bone strength versus saline control.
In plain wordsIn mice, teriparatide did not significantly increase femoral neck bone strength versus saline control.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeFemoral neck bone strength
Study
mousen = 24
Female C57BL/6 mice
Comparator
Saline control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
100 µg/kg five days a week · subcutaneous · three weeksAs given in this study (mouse).
Source sentences
Summary
Neither PTH nor ABL significantly increased bone strength at the femoral neck.
3 context sentences(design, population, supporting numbers)
Summary · context
The present study compared the effect of intermittent PTH (1-34) and ABL on bone tissue directly mole-to-mole in female mice.
Summary · context
Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12).
Summary · context
The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks.
Show in the study text Report a problemFND-3395369416

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 2
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice.

Summary

Results from this study16

Version history

Subjects

Publication types

MeSH terms

Keywords