Skip to content

Study · Animal study (in vivo) · sheep · 2021

5 results

Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.

White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ

American journal of physiology. Endocrinology and metabolism3 May 2021Cited by 9 (Europe PMC)

PMID33938236 (opens in a new tab)PMCIDPMC8285601 (opens in a new tab)DOI10.1152/ajpendo.00623.2020 (opens in a new tab)PepBankPUB-33938236
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, a 1-week IGF‑1 LR3 infusion lowered plasma insulin concentrations versus vehicle control.

    In plain wordsIn fetal sheep, IGF‑1 LR3 lowered insulin levels in the blood compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFetal plasma insulin concentration
    Study

    sheepn = 17

    Late gestation fetal sheep
    Comparator
    Vehicle control
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · infusion · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Plasma insulin and glucose concentrations in IGF-1 fetuses were lower compared with CON (P = 0.0135 and P = 0.0012, respectively).
    1 context sentence
    Summary · context
    Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 with low affinity for the IGF binding proteins and high affinity for the IGF-1 receptor, or vehicle control (CON, n = 9).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, a 1-week IGF‑1 LR3 infusion lowered plasma glucose concentrations versus vehicle control.

    In plain wordsIn fetal sheep, IGF‑1 LR3 lowered blood glucose compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFetal plasma glucose concentration
    Study

    sheepn = 17

    Late gestation fetal sheep
    Comparator
    Vehicle control
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · infusion · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Plasma insulin and glucose concentrations in IGF-1 fetuses were lower compared with CON (P = 0.0135 and P = 0.0012, respectively).
    1 context sentence
    Summary · context
    Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 with low affinity for the IGF binding proteins and high affinity for the IGF-1 receptor, or vehicle control (CON, n = 9).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, IGF‑1 LR3 infusion lowered insulin secretion during the GSIS study versus vehicle control.

    In plain wordsIn fetal sheep, IGF‑1 LR3 reduced the insulin response to glucose compared with vehicle.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFetal glucose-stimulated insulin secretion (GSIS) in vivo
    Study

    sheepn = 15

    Late gestation fetal sheep
    Comparator
    Vehicle control
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · infusion · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    During the GSIS study, IGF-1 fetuses had lower insulin secretion compared with CON (P = 0.0453).
    2 context sentences
    Summary · context
    Fetal GSIS was measured with a hyperglycemic clamp (IGF-1, n = 8; CON, n = 7).
    Summary · context
    Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 with low affinity for the IGF binding proteins and high affinity for the IGF-1 receptor, or vehicle control (CON, n = 9).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, IGF‑1 LR3 infusion did not change pancreatic insulin content.

    In plain wordsIn fetal sheep, IGF‑1 LR3 did not change the amount of insulin stored in the pancreas.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changePancreatic insulin content
    Study

    sheepn: not reported in source

    Late gestation fetal sheep
    Comparator
    Vehicle control
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · infusion · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    without differences in pancreatic insulin content.
    1 context sentence
    Summary · context
    Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 with low affinity for the IGF binding proteins and high affinity for the IGF-1 receptor, or vehicle control (CON, n = 9).
  5. 05LabEx vivo tissueEfficacy outcome

    In fetal sheep islets isolated after IGF‑1 LR3 infusion, glucose-stimulated insulin secretion remained lower than in islets from vehicle control fetuses.

    In plain wordsIn islets taken from fetal sheep given IGF‑1 LR3, insulin release stayed lower than in islets from vehicle-treated fetuses.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseGlucose-stimulated insulin secretion in isolated islets
    Study

    sheepn = 15

    Late gestation fetal sheep
    Comparator
    Vehicle control
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · infusion · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    In vitro, glucose-stimulated insulin secretion remained lower in islets isolated from IGF-1 fetuses (P = 0.0447).
    2 context sentences
    Summary · context
    Fetal islets were isolated, and insulin secretion was assayed in static incubations (IGF-1, n = 8; CON, n = 7).
    Summary · context
    Late gestation fetal sheep received infusions with IGF-1 LR3 (IGF-1, n = 8), an analog of IGF-1 with low affinity for the IGF binding proteins and high affinity for the IGF-1 receptor, or vehicle control (CON, n = 9).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.