In high-risk preterm infants, Cerebrolysin plus routine intervention reduced failed gross motor development compared with routine intervention alone.
In plain wordsIn high-risk preterm infants, Cerebrolysin plus routine intervention reduced failed gross motor development compared with routine intervention alone.
- Peptide
- Cerebrolysin
- Outcome
- DecreaseFailed gross motor development at 12 months corrected age
- Study
n: not reported in source
- Comparator
- Routine early intervention alone
- Analysis
- Primary
- Outcome group
- Exercise and physical function · Nervous system and cognition
- Studied dose
- 0.1 mL/kg body weight every week · injection · 3 monthsAs given in this study (human).
Measurements
- Failed gross motor development
- 33%
- Cerebrolysin
- Failed gross motor development
- 70%
- Routine intervention
- Infants with failed gross motor development
- 10 infants
- Cerebrolysin plus routine intervention; 12 months corrected age
- Infants with failed gross motor development
- 21 infants
- Routine intervention alone; 12 months corrected age
- P value for failed gross motor development
- 0.009
- Cerebrolysin plus routine intervention versus routine intervention alone; 12 months corrected age
Source sentences
Cerebrolysin group had a significant lower number of infants diagnosed with failed gross motor development compared to infants in the routine intervention group [10 (33%) versus 21 (70%), p = 0.009].
3 context sentences(design, population, supporting numbers)
The primary outcome was the rate of failure of the gross motor assessment at 12 months of corrected age and secondary outcomes included fine motor, language, and personal social development at 12 months corrected post-natal age as assessed by Denver Developmental Screening Test II.
In a randomized controlled trial, high-risk preterm infants < 32 weeks' gestation who have abnormal neurological assessment at two months corrected post-natal age were randomized at 6 months corrected post natal age
to receive either early intervention program or early intervention program plus Cerebrolysin injection of 0.1 mL/kg body weight every week for 3 months as an adjuvant therapy.