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Study · Measured the body's own peptide · 2021

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Parent-Infant Skin-to-Skin Contact and Stress Regulation: A Systematic Review of the Literature.

Ionio C, Ciuffo G, Landoni M

International journal of environmental research and public health28 Apr 2021Cited by 71 (Europe PMC)

PMID33924970 (opens in a new tab)PMCIDPMC8124223 (opens in a new tab)DOI10.3390/ijerph18094695 (opens in a new tab)PepBankPUB-33924970
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Summary

Several studies have focused on neonatal maternal separation (MS) to investigate behavioural and neuroendocrine reactions to lack of contact, but only a few have focused on early separation in the first days or weeks after birth. This literature review investigates the vital importance of contact and touch by exploring how skin-to-skin contact (SSC) regulates stress in the mother-infant relationship. Various databases such as PubMed, Scopus, and ScienceDirect were searched for literature published between 2015 and 2020. From 1141 articles, 22 were declared eligible. The reviewed articles showed how SSC regulates child stress by biological indicators such as the autonomic nervous system (ANS), heart rate variability (HRV), cortisol, and oxytocin. This research concludes the importance of SSC for stress regulation, especially during the COVID-19 pandemic. With no research to date indicating a possible risk of neonatal COVID-19 transmission following SSC, SSC should continue to be practiced for all women, as recommended by the WHO.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelSystematic reviewOther

    In a systematic review of studies of parent-infant skin-to-skin contact, the body's own oxytocin was one of several biological indicators, with cortisol and heart rate variability, that the reviewed articles used for stress regulation.

    In plain wordsA review of skin-to-skin contact studies named the body's own oxytocin as one of several indicators of infant stress.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedOxytocin as indicator of stress regulation by skin-to-skin contact
    Study

    n: not reported in source

    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    The reviewed articles showed how SSC regulates child stress by biological indicators such as the autonomic nervous system (ANS), heart rate variability (HRV), cortisol, and oxytocin.
    2 context sentences
    Summary · context
    Various databases such as PubMed, Scopus, and ScienceDirect were searched for literature published between 2015 and 2020.
    Summary · context
    From 1141 articles, 22 were declared eligible.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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