Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin.

An JH, Lee HJ, Yoon MS, Kim DH

Annals of dermatology1 May 2019Cited by 19 (Europe PMC)

PMID33911590PMCIDPMC7992733DOI10.5021/ad.2019.31.3.263PepBankPUB-33911590

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. 1 result from people.

01HumanRandomized controlled trialEfficacy outcome
In Korean females, microneedle patch/AHP-8 improved wrinkles more than microneedle patch alone.
In plain wordsIn Korean females, microneedle patch/AHP-8 improved wrinkles more than microneedle patch alone.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseWrinkle improvement versus patch alone
Study
n: not reported in source
Comparator
Microneedle patch alone
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated · microneedle patch · 29 daysAs given in this study (human).
Measurements
P value
< 0.05
microneedle patch/AHP-8 versus patch alone, wrinkle
Source sentences
Summary
Treatment with microneedle patch/AHP-8 and microneedle patch/EGF showed statistically significant improvements in wrinkle compared with microneedle patch alone (p<0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 52 Korean females were enrolled in a double-blind, randomized, controlled, split-face trial.
Summary · context
The subjects were divided into 3 groups: (1) microneedle patch alone, (2) microneedle patch/AHP-8, and (3) microneedle patch/EGF.
Summary · context
The treatment was applied on the periorbital and nasolabial fold area for 4 hours to completely dissolve the microstructures once per week for 29 days.
Report a problemFND-3391159003

Studies that did not test the peptide alone3

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

02HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialEfficacy outcome
In Korean females, wrinkles improved in all patch groups, including patch alone and patch/AHP-8, on day 29.
In plain wordsWrinkles improved in all patch groups, including patch alone and patch/AHP-8, in Korean females on day 29.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseWrinkle improvement shared by all groups
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
P value
< 0.01
wrinkle improvement in all groups on day 29
Source sentences
Summary
On day 29 after application, statistically significant improvements in wrinkle and skin hydration were observed in all groups (p<0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 52 Korean females were enrolled in a double-blind, randomized, controlled, split-face trial.
Summary · context
The subjects were divided into 3 groups: (1) microneedle patch alone, (2) microneedle patch/AHP-8, and (3) microneedle patch/EGF.
Summary · context
The treatment was applied on the periorbital and nasolabial fold area for 4 hours to completely dissolve the microstructures once per week for 29 days.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3391159001
03HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialEfficacy outcome
In Korean females, skin hydration improved in all patch groups, including patch alone and patch/AHP-8, on day 29.
In plain wordsSkin hydration improved in all patch groups, including patch alone and patch/AHP-8, in Korean females on day 29.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSkin hydration improvement shared by all groups
Study
n = 50
Outcome group
Skin and hair · Skin and wound
Measurements
P value
< 0.01
skin hydration improvement in all groups on day 29
Source sentences
Summary
On day 29 after application, statistically significant improvements in wrinkle and skin hydration were observed in all groups (p<0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 52 Korean females were enrolled in a double-blind, randomized, controlled, split-face trial.
Summary · context
The subjects were divided into 3 groups: (1) microneedle patch alone, (2) microneedle patch/AHP-8, and (3) microneedle patch/EGF.
Summary · context
The treatment was applied on the periorbital and nasolabial fold area for 4 hours to completely dissolve the microstructures once per week for 29 days.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3391159002
04HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialSafety outcome
No serious adverse effects were noted across the Korean trial's patch groups, including patch/AHP-8.
In plain wordsNo serious adverse effects were noted across the patch groups, including patch/AHP-8, in Korean females.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
Not applicableSerious adverse effects across patch groups
Study
n = 50
Outcome group
Adverse events · Skin and wound
Source sentences
Summary
No serious adverse effects were noted.
4 context sentences(design, population, supporting numbers)
Summary · context
Fifty subjects (96.2%) completed this clinical study.
Summary · context
A total of 52 Korean females were enrolled in a double-blind, randomized, controlled, split-face trial.
Summary · context
The subjects were divided into 3 groups: (1) microneedle patch alone, (2) microneedle patch/AHP-8, and (3) microneedle patch/EGF.
Summary · context
The treatment was applied on the periorbital and nasolabial fold area for 4 hours to completely dissolve the microstructures once per week for 29 days.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3391159004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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