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Study · Animal study (in vivo) · mouse · 2021

6 results

Assessment of renal fibrosis and anti-fibrotic agents using a novel diagnostic and stain-free second-harmonic generation platform.

Bhuiyan S, Shen M, Chelvaretnam S, Tan AY, Ho G, Hossain MA, Widdop RE, Samuel CS

FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 May 2021Cited by 20 (Europe PMC)

PMID33908676 (opens in a new tab)DOI10.1096/fj.202002053rrr (opens in a new tab)PepBankPUB-33908676
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In UUO-injured mice, B7‑33 increased renal matrix metalloproteinase-2 versus UUO alone.

    In plain wordsIn mice with ureter obstruction, B7‑33 increased kidney matrix metalloproteinase-2 compared with untreated obstruction.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    IncreaseRenal matrix metalloproteinase-2
    Study

    mousen: not reported in source

    Unilateral ureteric obstruction
    Comparator
    UUO alone
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    0.25 mg/kg/day · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Relaxin or B7-33 treatment also increased renal matrix metalloproteinase-2 and reduced tissue inhibitor of metalloproteinase-1 levels (all P < .01 vs UUO alone).
    2 context sentences
    Summary · context
    Furthermore, in UUO-injured mice treated with the relaxin family peptide receptor-1 agonists, relaxin (0.5 mg/kg/day) or B7-33 (0.25 mg/kg/day), or angiotensin converting enzyme-inhibitor, perindopril (1 mg/kg/day) over the 7-day period,
    Summary · context
    This study compared SHG imaging of renal fibrosis in mice with unilateral ureteric obstruction (UUO), to that of Masson's trichrome staining (MTS) and immunohistochemistry (IHC) of collagen I.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In UUO-injured mice, B7‑33 reduced tissue inhibitor of metalloproteinase-1 versus UUO alone.

    In plain wordsIn mice with ureter obstruction, B7‑33 reduced tissue inhibitor of metalloproteinase-1 compared with untreated obstruction.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    DecreaseTissue inhibitor of metalloproteinase-1
    Study

    mousen: not reported in source

    Unilateral ureteric obstruction
    Comparator
    UUO alone
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    0.25 mg/kg/day · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Relaxin or B7-33 treatment also increased renal matrix metalloproteinase-2 and reduced tissue inhibitor of metalloproteinase-1 levels (all P < .01 vs UUO alone).
    2 context sentences
    Summary · context
    Furthermore, in UUO-injured mice treated with the relaxin family peptide receptor-1 agonists, relaxin (0.5 mg/kg/day) or B7-33 (0.25 mg/kg/day), or angiotensin converting enzyme-inhibitor, perindopril (1 mg/kg/day) over the 7-day period,
    Summary · context
    This study compared SHG imaging of renal fibrosis in mice with unilateral ureteric obstruction (UUO), to that of Masson's trichrome staining (MTS) and immunohistochemistry (IHC) of collagen I.

Studies that did not test the peptide alone4

In this study, B7-33 (single-chain relaxin-2 analog) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking B7-33 (single-chain relaxin-2 analog).

  1. 03AnimalNot a test of B7-33 (single-chain relaxin-2 analog) aloneAnimal study (in vivo)Efficacy outcome

    In UUO-injured mice, treatments including B7‑33 prevented renal fibrosis.

    In plain wordsIn mice with ureter obstruction, treatments including B7‑33 prevented kidney fibrosis.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    DecreaseRenal fibrosis
    Study

    mousen: not reported in source

    Unilateral ureteric obstruction
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Furthermore, in UUO-injured mice treated with the relaxin family peptide receptor-1 agonists, relaxin (0.5 mg/kg/day) or B7-33 (0.25 mg/kg/day), or angiotensin converting enzyme-inhibitor, perindopril (1 mg/kg/day) over the 7-day period, only the HistoIndex platform determined that the drug-induced…
    1 context sentence
    Summary · context
    This study compared SHG imaging of renal fibrosis in mice with unilateral ureteric obstruction (UUO), to that of Masson's trichrome staining (MTS) and immunohistochemistry (IHC) of collagen I.

    In this study, B7-33 (single-chain relaxin-2 analog) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking B7-33 (single-chain relaxin-2 analog).

  2. 04AnimalNot a test of B7-33 (single-chain relaxin-2 analog) aloneAnimal study (in vivo)Efficacy outcome

    In UUO-injured mice, fibrosis prevention across treatments including B7‑33 correlated with reduced collagen fiber thickness.

    In plain wordsIn mice with ureter obstruction, fibrosis prevention across treatments including B7‑33 was linked to thinner collagen fibers.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    DecreaseCollagen fiber thickness
    Study

    mousen: not reported in source

    Unilateral ureteric obstruction
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    only the HistoIndex platform determined that the drug-induced prevention of renal fibrosis correlated with significantly reduced collagen fiber thickness and collagen-to-tissue cross reticulation ratio, but increased collagen fiber counts.
    1 context sentence
    Summary · context
    This study compared SHG imaging of renal fibrosis in mice with unilateral ureteric obstruction (UUO), to that of Masson's trichrome staining (MTS) and immunohistochemistry (IHC) of collagen I.

    In this study, B7-33 (single-chain relaxin-2 analog) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking B7-33 (single-chain relaxin-2 analog).

  3. 05AnimalNot a test of B7-33 (single-chain relaxin-2 analog) aloneAnimal study (in vivo)Efficacy outcome

    In UUO-injured mice, fibrosis prevention across treatments including B7‑33 correlated with reduced collagen-to-tissue cross reticulation ratio.

    In plain wordsIn mice with ureter obstruction, fibrosis prevention across treatments including B7‑33 was linked to a lower collagen cross-reticulation ratio.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    DecreaseCollagen-to-tissue cross reticulation ratio
    Study

    mousen: not reported in source

    Unilateral ureteric obstruction
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    only the HistoIndex platform determined that the drug-induced prevention of renal fibrosis correlated with significantly reduced collagen fiber thickness and collagen-to-tissue cross reticulation ratio, but increased collagen fiber counts.
    1 context sentence
    Summary · context
    This study compared SHG imaging of renal fibrosis in mice with unilateral ureteric obstruction (UUO), to that of Masson's trichrome staining (MTS) and immunohistochemistry (IHC) of collagen I.

    In this study, B7-33 (single-chain relaxin-2 analog) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking B7-33 (single-chain relaxin-2 analog).

  4. 06AnimalNot a test of B7-33 (single-chain relaxin-2 analog) aloneAnimal study (in vivo)Efficacy outcome

    In UUO-injured mice, fibrosis prevention across treatments including B7‑33 correlated with increased collagen fiber counts.

    In plain wordsIn mice with ureter obstruction, fibrosis prevention across treatments including B7‑33 was linked to more collagen fibers.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    IncreaseCollagen fiber counts
    Study

    mousen: not reported in source

    Unilateral ureteric obstruction
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    only the HistoIndex platform determined that the drug-induced prevention of renal fibrosis correlated with significantly reduced collagen fiber thickness and collagen-to-tissue cross reticulation ratio, but increased collagen fiber counts.
    1 context sentence
    Summary · context
    This study compared SHG imaging of renal fibrosis in mice with unilateral ureteric obstruction (UUO), to that of Masson's trichrome staining (MTS) and immunohistochemistry (IHC) of collagen I.

    In this study, B7-33 (single-chain relaxin-2 analog) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking B7-33 (single-chain relaxin-2 analog).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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