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Study · Animal study (in vivo) · 2021

11 results

Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1-42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation.

Jiang J, Chang X, Nie Y, Shen Y, Liang X, Peng Y, Chang M

ACS chemical neuroscience16 Apr 2021Cited by 34 (Europe PMC)

PMID33861582 (opens in a new tab)DOI10.1021/acschemneuro.0c00782 (opens in a new tab)PepBankPUB-33861582
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    Central MOTS‑c enhanced object and location recognition memory formation and consolidation.

    In plain wordsIn animals, MOTS‑c given centrally improved memory formation and consolidation for objects and locations.

    Peptide
    MOTS-c
    Outcome
    IncreaseObject and location recognition memory formation and consolidation
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · centralAs given in this study.

    Source sentences

    Summary
    central MOTS-c not only enhanced object and location recognition memory formation and consolidation
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    Central MOTS‑c ameliorated the memory deficit induced by Aβ1-42.

    In plain wordsIn animals, MOTS‑c given centrally eased the memory loss caused by Aβ1-42.

    Peptide
    MOTS-c
    Outcome
    IncreaseMemory deficit induced by Aβ1-42
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · centralAs given in this study.

    Source sentences

    Summary
    The results showed that central MOTS-c not only enhanced object and location recognition memory formation and consolidation but also ameliorated the memory deficit induced by Aβ1-42 or LPS.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    Central MOTS‑c ameliorated the memory deficit induced by LPS.

    In plain wordsIn animals, MOTS‑c given centrally eased the memory loss caused by LPS.

    Peptide
    MOTS-c
    Outcome
    IncreaseMemory deficit induced by LPS
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · centralAs given in this study.

    Source sentences

    Summary
    The results showed that central MOTS-c not only enhanced object and location recognition memory formation and consolidation but also ameliorated the memory deficit induced by Aβ1-42 or LPS.
  4. 04AnimalAnimal study (in vivo)Mechanism

    The memory-ameliorating effects of MOTS‑c were blocked by the AMPK inhibitor dorsomorphin.

    In plain wordsIn animals, the memory benefit of MOTS‑c was blocked by an AMPK inhibitor.

    Peptide
    MOTS-c
    Outcome
    Not applicableAMPK dependence of memory effect
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The memory-ameliorating effects of MOTS-c could be blocked by AMPK inhibitor dorsomorphin.
  5. 05AnimalAnimal study (in vivo)Mechanism

    MOTS‑c treatment significantly increased AMPK phosphorylation in the hippocampus.

    In plain wordsIn animals, MOTS‑c raised AMPK activation in the hippocampus, a memory region of the brain.

    Peptide
    MOTS-c
    Outcome
    IncreaseHippocampal AMPK phosphorylation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment significantly increased the phosphorylation of AMPK
  6. 06AnimalAnimal study (in vivo)Mechanism

    MOTS‑c treatment did not increase phosphorylation of ERK, JNK and p38 in the hippocampus.

    In plain wordsIn animals, MOTS‑c did not raise ERK, JNK or p38 activation in the hippocampus.

    Peptide
    MOTS-c
    Outcome
    No significant changeHippocampal ERK, JNK and p38 phosphorylation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MOTS-c treatment significantly increased the phosphorylation of AMPK but not ERK, JNK, and p38 in the hippocampus.
  7. 07AnimalAnimal study (in vivo)Pharmacokinetics

    Peripherally administered MOTS‑c did not cross the blood-brain barrier.

    In plain wordsIn animals, MOTS‑c given outside the brain did not cross the blood-brain barrier.

    Peptide
    MOTS-c
    Outcome
    Not applicableBlood-brain barrier crossing of peripheral MOTS-c
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study.

    Source sentences

    Summary
    In addition, we found that peripheral administration of MOTS-c does not cross the blood-brain barrier (BBB) and plays an effect.

Studies that did not test the peptide alone4

In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MOTS-c.

  1. 08AnimalNot a test of MOTS-c aloneAnimal study (in vivo)Efficacy outcome

    Intranasal or intravenous MP, a cell-penetrating MOTS‑c analogue, showed good memory performance on memory formation in the NOR task.

    In plain wordsIn animals, a MOTS‑c analogue linked to a carrier peptide gave good memory formation in a recognition test.

    Peptide
    MOTS-c
    Outcome
    IncreaseMemory formation with cell-penetrating MOTS-c analogue (MP)
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Then in the NOR task, intranasal or intravenous MP (cell-penetrating MOTS-c analogue) showed good memory performance on memory formation, memory consolidation, and memory impairment.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

  2. 09AnimalNot a test of MOTS-c aloneAnimal study (in vivo)Efficacy outcome

    Intranasal or intravenous MP showed good memory performance on memory consolidation in the NOR task.

    In plain wordsIn animals, a MOTS‑c analogue linked to a carrier peptide gave good memory consolidation in a recognition test.

    Peptide
    MOTS-c
    Outcome
    IncreaseMemory consolidation with cell-penetrating MOTS-c analogue (MP)
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Then in the NOR task, intranasal or intravenous MP (cell-penetrating MOTS-c analogue) showed good memory performance on memory formation, memory consolidation, and memory impairment.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

  3. 10AnimalNot a test of MOTS-c aloneAnimal study (in vivo)Efficacy outcome

    Intranasal or intravenous MP showed good memory performance on memory impairment in the NOR task.

    In plain wordsIn animals, a MOTS‑c analogue linked to a carrier peptide gave good memory performance despite impairment in a recognition test.

    Peptide
    MOTS-c
    Outcome
    IncreaseMemory impairment with cell-penetrating MOTS-c analogue (MP)
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Then in the NOR task, intranasal or intravenous MP (cell-penetrating MOTS-c analogue) showed good memory performance on memory formation, memory consolidation, and memory impairment.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

  4. 11AnimalNot a test of MOTS-c aloneAnimal study (in vivo)Pharmacokinetics

    Near-infrared fluorescence showed the real-time brain biodistribution of MP after intranasal or intravenous infusion.

    In plain wordsIn animals, imaging showed where a MOTS‑c analogue went in the brain after nasal or intravenous infusion.

    Peptide
    MOTS-c
    Outcome
    Not applicableBrain biodistribution of MP after intranasal or intravenous infusion
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Nervous system and cognition

    Source sentences

    Summary
    Near-infrared fluorescent experiments showed the real-time biodistribution in brain after intranasal or intravenous infusion of MP.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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