Skip to content

Study · Randomized controlled trial · n = 111 · 2021

5 results

Intranasal oxytocin increases state anhedonia following imagery training of positive social outcomes in individuals lower in extraversion, trust-altruism, and openness to experience.

Wong SF, Vaillancourt S, Grossman S, Kelly-Turner K, Blackwell SE, Ellenbogen MA

International journal of psychophysiology : official journal of the International Organization of Psychophysiology8 Apr 2021Cited by 5 (Europe PMC)

PMID33839197 (opens in a new tab)DOI10.1016/j.ijpsycho.2021.03.013 (opens in a new tab)PepBankPUB-33839197
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no main effect on anhedonia compared with placebo.

    In plain wordsIn university students, oxytocin spray had no overall effect on lack of pleasure compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAnhedonia, main effect of oxytocin
    Study

    n = 111

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    There were no main effects of imagery type and drug, and no interaction effect on anhedonia and social activity, measured respectively via self-report and a behavioural task.
    1 context sentence
    Summary · context
    University students (N = 111) were randomised to self-administer intranasal oxytocin or placebo, followed by a single session of positive social or non-social imagery training that required participants to imagine 64 positive scenarios occurring in either a social or non-social context, respectively.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In university students, intranasal oxytocin had no main effect on a behavioural social activity task compared with placebo.

    In plain wordsIn university students, oxytocin spray had no overall effect on a social activity task compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial activity, main effect of oxytocin
    Study

    n = 111

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    There were no main effects of imagery type and drug, and no interaction effect on anhedonia and social activity, measured respectively via self-report and a behavioural task.
    1 context sentence
    Summary · context
    University students (N = 111) were randomised to self-administer intranasal oxytocin or placebo, followed by a single session of positive social or non-social imagery training that required participants to imagine 64 positive scenarios occurring in either a social or non-social context, respectively.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In university students, there was no interaction between oxytocin and imagery type on anhedonia.

    In plain wordsIn university students, the effect of oxytocin spray on lack of pleasure did not depend on the imagery type.

    Peptide
    Oxytocin
    Outcome
    No significant changeAnhedonia, oxytocin by imagery type interaction
    Study

    n = 111

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    There were no main effects of imagery type and drug, and no interaction effect on anhedonia and social activity, measured respectively via self-report and a behavioural task.
    1 context sentence
    Summary · context
    University students (N = 111) were randomised to self-administer intranasal oxytocin or placebo, followed by a single session of positive social or non-social imagery training that required participants to imagine 64 positive scenarios occurring in either a social or non-social context, respectively.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In university students, there was no interaction between oxytocin and imagery type on the social activity task.

    In plain wordsIn university students, the effect of oxytocin spray on a social activity task did not depend on the imagery type.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial activity, oxytocin by imagery type interaction
    Study

    n = 111

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    There were no main effects of imagery type and drug, and no interaction effect on anhedonia and social activity, measured respectively via self-report and a behavioural task.
    1 context sentence
    Summary · context
    University students (N = 111) were randomised to self-administer intranasal oxytocin or placebo, followed by a single session of positive social or non-social imagery training that required participants to imagine 64 positive scenarios occurring in either a social or non-social context, respectively.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In university students low in extraversion, trust-altruism and openness to experience, intranasal oxytocin increased anhedonia versus placebo, only after positive social imagery training.

    In plain wordsIn students low in extraversion, trust and openness, oxytocin spray raised lack of pleasure compared with placebo, but only after positive social imagery training.

    Peptide
    Oxytocin
    Outcome
    IncreaseAnhedonia after positive social imagery in individuals low in extraversion, trust-altruism and openness
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Individuals low in extraversion, trust-altruism, and openness to experience reported significantly more anhedonia after receiving oxytocin relative to placebo, but only following imagery training of positive social outcomes.
    1 context sentence
    Summary · context
    University students (N = 111) were randomised to self-administer intranasal oxytocin or placebo, followed by a single session of positive social or non-social imagery training that required participants to imagine 64 positive scenarios occurring in either a social or non-social context, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.