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Study · Randomized controlled trial · n = 40 · 2021

2 results

Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity.

Ochiai H, Shiga T, Hoshino H, Horikoshi S, Kanno K, Wada T, Osakabe Y, Miura I, Yabe H

Psychopharmacology7 Apr 2021Cited by 5 (Europe PMC)

PMID33829308 (opens in a new tab)DOI10.1007/s00213-021-05807-w (opens in a new tab)PepBankPUB-33829308
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy subjects, intranasal oxytocin shortened mismatch negativity latencies compared with placebo.

    In plain wordsIn healthy people, oxytocin spray shortened the brain's reaction time to a sound change compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseMismatch negativity latency
    Study

    n = 40

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants who received oxytocin had significantly shorter MMN latencies than those who received a placebo.
    2 context sentences
    Summary · context
    Forty healthy subjects were randomly assigned to either the oxytocin or placebo group.
    Summary · context
    ERPs were recorded during the oddball task for all subjects before and after a 24 international unit (IU) intranasal administration, and MMN was compared between the two groups.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy subjects, intranasal oxytocin had no significant effect on the change in mismatch negativity amplitude compared with placebo.

    In plain wordsIn healthy people, oxytocin spray did not change the strength of the brain's response to a sound change compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeChange in mismatch negativity amplitude
    Study

    n = 40

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin had no significant effect on the Change in MMN amplitude.
    2 context sentences
    Summary · context
    Forty healthy subjects were randomly assigned to either the oxytocin or placebo group.
    Summary · context
    ERPs were recorded during the oddball task for all subjects before and after a 24 international unit (IU) intranasal administration, and MMN was compared between the two groups.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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