Skip to content

Study · Animal study (in vivo) · rat · 2021

4 results

Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis.

Shakova FM, Kirova YI, Silachev DN, Romanova GA, Morozov SG

Brain sciences4 Mar 2021Cited by 8 (Europe PMC)

PMID33806692 (opens in a new tab)PMCIDPMC8002020 (opens in a new tab)DOI10.3390/brainsci11030325 (opens in a new tab)PepBankPUB-33806692
Download PDFPubMedAsk about this study
Jump to 4 results

Summary

The pharmacological induction and activation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), a key regulator of ischemic brain tolerance, is a promising direction in neuroprotective therapy. Pharmacological agents with known abilities to modulate cerebral PGC-1α are scarce. This study focused on the potential PGC-1α-modulating activity of Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) and Semax (ACTH(4-7) analog) in a rat model of photochemical-induced thrombosis (PT) in the prefrontal cortex. Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each. The expression of PGC-1α and PGC-1α-dependent protein markers of mitochondriogenesis, angiogenesis, and synaptogenesis was measured in the penumbra via immunoblotting at Days 1, 3, 7, and 21 after PT. The nuclear content of PGC-1α was measured immunohistochemically. The suppression of PGC-1α expression was observed in the penumbra from 24 h to 21 days following PT and reflected decreases in both the number of neurons and PGC-1α expression in individual neurons. Administration of Mexidol or Semax was associated with preservation of the neuron number and neuronal expression of PGC-1α, stimulation of the nuclear translocation of PGC-1α, and increased contents of protein markers for PGC-1α activation. This study opens new prospects for the pharmacological modulation of PGC-1α in the ischemic brain.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photochemically induced thrombosis, Semax was associated with preservation of the neuron number in the penumbra.

    In plain wordsIn rats with an induced stroke, Semax was linked to fewer lost nerve cells near the damaged area.

    Peptide
    Semax
    Outcome
    IncreaseNeuron number in the penumbra
    Study

    ratn: not reported in source

    Photochemically induced thrombosis in the prefrontal cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    25 μg/kg · intranasal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of Mexidol or Semax was associated with preservation of the neuron number and neuronal expression of PGC-1α, stimulation of the nuclear translocation of PGC-1α, and increased contents of protein markers for PGC-1α activation.
    2 context sentences
    Summary · context
    This study focused on the potential PGC-1α-modulating activity of Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) and Semax (ACTH(4-7) analog) in a rat model of photochemical-induced thrombosis (PT) in the prefrontal cortex.
    Summary · context
    Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photochemically induced thrombosis, Semax was associated with preserved neuronal expression of PGC-1α.

    In plain wordsIn rats with an induced stroke, Semax was linked to preserved levels of the protective protein PGC-1α in nerve cells.

    Peptide
    Semax
    Outcome
    IncreaseNeuronal PGC-1α expression
    Study

    ratn: not reported in source

    Photochemically induced thrombosis in the prefrontal cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    25 μg/kg · intranasal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of Mexidol or Semax was associated with preservation of the neuron number and neuronal expression of PGC-1α, stimulation of the nuclear translocation of PGC-1α, and increased contents of protein markers for PGC-1α activation.
    2 context sentences
    Summary · context
    This study focused on the potential PGC-1α-modulating activity of Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) and Semax (ACTH(4-7) analog) in a rat model of photochemical-induced thrombosis (PT) in the prefrontal cortex.
    Summary · context
    Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photochemically induced thrombosis, Semax was associated with stimulation of the nuclear translocation of PGC-1α.

    In plain wordsIn rats with an induced stroke, Semax was linked to more PGC-1α moving into the cell nucleus.

    Peptide
    Semax
    Outcome
    IncreaseNuclear translocation of PGC-1α
    Study

    ratn: not reported in source

    Photochemically induced thrombosis in the prefrontal cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    25 μg/kg · intranasal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of Mexidol or Semax was associated with preservation of the neuron number and neuronal expression of PGC-1α, stimulation of the nuclear translocation of PGC-1α, and increased contents of protein markers for PGC-1α activation.
    2 context sentences
    Summary · context
    This study focused on the potential PGC-1α-modulating activity of Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) and Semax (ACTH(4-7) analog) in a rat model of photochemical-induced thrombosis (PT) in the prefrontal cortex.
    Summary · context
    Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photochemically induced thrombosis, Semax was associated with increased contents of protein markers of PGC-1α activation.

    In plain wordsIn rats with an induced stroke, Semax was linked to higher levels of proteins that show PGC-1α activation.

    Peptide
    Semax
    Outcome
    IncreaseProtein markers of PGC-1α activation
    Study

    ratn: not reported in source

    Photochemically induced thrombosis in the prefrontal cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    25 μg/kg · intranasal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of Mexidol or Semax was associated with preservation of the neuron number and neuronal expression of PGC-1α, stimulation of the nuclear translocation of PGC-1α, and increased contents of protein markers for PGC-1α activation.
    2 context sentences
    Summary · context
    This study focused on the potential PGC-1α-modulating activity of Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) and Semax (ACTH(4-7) analog) in a rat model of photochemical-induced thrombosis (PT) in the prefrontal cortex.
    Summary · context
    Mexidol (100 mg/kg) was administered intraperitoneally, and Semax (25 μg/kg) was administered intranasally, for 7 days each.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 10:21 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.