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Study · Animal study (in vivo) · 2021

1 result

Network dynamics of hypothalamic feeding neurons.

Sweeney P, Sweeney P, Chen C, Rajapakse I, Cone RD

Proceedings of the National Academy of Sciences of the United States of America1 Apr 2021Cited by 14 (Europe PMC)

PMID33795520 (opens in a new tab)PMCIDPMC8040641 (opens in a new tab)DOI10.1073/pnas.2011140118 (opens in a new tab)PepBankPUB-33795520
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In vivo, setmelanotide rapidly increased basal activity of PVN MC4R neurons.

    In plain wordsIn animals, setmelanotide rapidly increased basal activity of hypothalamic MC4R neurons.

    Peptide
    Setmelanotide
    Outcome
    IncreaseBasal PVN MC4R neuronal activity
    Study

    n: not reported in source

    PVN MC4R neurons in vivo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pharmacological stimulation of MC4R with the therapeutic MC4R agonist setmelanotide rapidly increases basal PVN MC4R activity,
    1 context sentence
    Summary · context
    Here, we utilize in vivo single-cell endomicroscopic and mathematical approaches to determine the activity and network dynamics of PVN MC4R neurons in response to changes in energy state and pharmacological manipulation of central melanocortin receptors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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