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Study · In vitro (cells) · 2021

3 results

Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway.

Daziano G, Blondeau N, Béraud-Dufour S, Abderrahmani A, Rovère C, Heurteaux C, Mazella J, Lebrun P, Coppola T

Pharmacological research15 Mar 2021Cited by 11 (Europe PMC)

PMID33737242 (opens in a new tab)DOI10.1016/j.phrs.2021.105539 (opens in a new tab)PepBankPUB-33737242
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In pancreatic beta-cells, Mini-Spadin promoted beta-cell proliferation.

    In plain wordsIn cells, Mini-Spadin made insulin-producing beta-cells multiply.

    Peptide
    PE 22-28
    Outcome
    IncreaseBeta-cell proliferation
    Study

    n: not reported in source

    pancreatic beta-cells
    Outcome group
    Islet protection · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Mini-Spadin promotes beta-cell proliferation, suggesting its possible regenerative effect.
    1 context sentence
    Summary · context
    In this study we tested two correlated hypothesis that 1/ the endogenous peptide released from sortilin, known as PE, that stimulates insulin secretion only in response to glucose, protects beta-cells against death induced by cytokines

Studies that did not test the peptide alone2

In this study, PE 22-28 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking PE 22-28.

  1. 02LabNot a test of PE 22-28 aloneIn vitro (cells)Efficacy outcome

    In pancreatic beta-cells, PE and its derivatives, pooled, protected cells against interleukin-1β-induced death through a rise of intracellular calcium.

    In plain wordsIn cells, PE and its derivatives together protected insulin-producing beta-cells from death caused by interleukin-1β.

    Peptide
    PE 22-28
    Outcome
    IncreaseBeta-cell protection against IL-1β-induced death
    Study

    n: not reported in source

    pancreatic beta-cells
    Outcome group
    Islet protection · Endocrine and hormones

    Source sentences

    Summary
    We show that PE and its derivatives by inducing a rise of intracellular calcium concentration by depolarizing the membrane protect beta-cells against death induced by Interleukin-1β.
    1 context sentence
    Summary · context
    In this study we tested two correlated hypothesis that 1/ the endogenous peptide released from sortilin, known as PE, that stimulates insulin secretion only in response to glucose, protects beta-cells against death induced by cytokines

    In this study, PE 22-28 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking PE 22-28.

  2. 03LabNot a test of PE 22-28 aloneIn vitro (cells)Mechanism

    In pancreatic beta-cells, the protective effects of PE and its derivatives, pooled, relied on activation of the CaM-Kinase pathway and on phosphorylation and activation of CREB.

    In plain wordsIn cells, the protection by PE and its derivatives together depended on the CaM-kinase pathway and the factor CREB.

    Peptide
    PE 22-28
    Outcome
    IncreaseCaM-kinase and CREB activation
    Study

    n: not reported in source

    pancreatic beta-cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Using biochemical, confocal imaging and cell biology techniques, we reveal that the protective effects of PE and its derivatives rely on the activation of the CaM-Kinase pathway, and on the phosphorylation and activation of the transcription factor CREB.
    1 context sentence
    Summary · context
    In this study we tested two correlated hypothesis that 1/ the endogenous peptide released from sortilin, known as PE, that stimulates insulin secretion only in response to glucose, protects beta-cells against death induced by cytokines

    In this study, PE 22-28 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking PE 22-28.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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