Long non-coding RNA NEAT1 functions as a competing endogenous RNA to regulate S100A9 expression by sponging miR-196a-5p in rosacea.

Wang L, Wang YJ, Hao D, Wang XY, Li XX, Zhao Q, Li YM, He G, Jiang X

Journal of dermatological science27 Feb 2021Cited by 10 (Europe PMC)

PMID33678493DOI10.1016/j.jdermsci.2021.02.005PepBankPUB-33678493

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In HaCaT keratinocytes, treatment with LL37 was associated with upregulation of the long non-coding RNA NEAT1.
In plain wordsIn lab-grown skin cells, LL37 treatment went with higher levels of the RNA NEAT1.
Peptide
LL-37
Outcome
IncreaseNEAT1 expression in LL37-treated HaCaT cells
Study
humann: not reported in source
HaCaT cells
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
NEAT1 was upregulated in rosacea skin and in LL37-treated HaCaT cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of NEAT1 in LL37-treated HaCaT cells was identified by in vitro experiments.
Report a problemFND-3367849301

Studies that did not test the peptide alone2

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

02LabNot a test of LL-37 aloneIn vitro (cells)Mechanism
In cells challenged with LL37, knockdown of NEAT1 reduced inflammatory damage; LL37 served as the challenge and NEAT1 knockdown was the tested treatment.
In plain wordsIn lab-grown skin cells, switching off NEAT1 reduced inflammatory damage; LL37 was used only to provoke inflammation.
Peptide
LL-37
Outcome
DecreaseInflammatory damage after NEAT1 knockdown in LL37-treated cells
Study
humann: not reported in source
HaCaT cells
Outcome group
Inflammation markers · Skin and wound
Source sentences
Summary
Moreover, inflammatory damage was able to be reduced in vitro after knockdown of NEAT1.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of NEAT1 in LL37-treated HaCaT cells was identified by in vitro experiments.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-3367849302
03LabNot a test of LL-37 aloneIn vitro (cells)Mechanism
In cells challenged with LL37, NEAT1 interacted directly with miR-196a-5p, and downregulating miR-196a-5p reversed the effect of NEAT1 siRNA on S100A9.
In plain wordsIn lab-grown skin cells, NEAT1 bound miR-196a-5p, which affected S100A9; LL37 was used only as the challenge.
Peptide
LL-37
Outcome
Not applicableNEAT1 interaction with miR-196a-5p and S100A9
Study
humann: not reported in source
HaCaT cells
Outcome group
Receptor activity and mechanism · Skin and wound
Source sentences
Summary
Finally, NEAT1 was able to directly interact with miR-196a-5p, and downregulating miR-196a-5p was efficient in reversing the influence of NEAT1 siRNA on S100A9.
1 context sentence(design, population, supporting numbers)
Summary · context
The role of NEAT1 in LL37-treated HaCaT cells was identified by in vitro experiments.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-3367849303

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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