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Study · In vitro (cells) · 2021

12 results

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.

Akar S, Duran T, Azzawri AA, Koçak N, Çelik Ç, Yıldırım Hİ

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology1 Mar 2021Cited by 6 (Europe PMC)

PMID33645410 (opens in a new tab)DOI10.1080/01443615.2020.1854696 (opens in a new tab)PepBankPUB-33645410
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In HeLa cells, 5MQ significantly inhibited proliferation in a concentration- and time-dependent manner.

    In plain wordsIn cells, 5MQ reduced HeLa cancer cell proliferation as concentration and exposure time increased.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseHeLa proliferation
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    5MQ significantly inhibited HeLa cell proliferation in a concentration and time-dependent manner.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  2. 02LabIn vitro (cells)Efficacy outcome

    In HeLa cells, 5MQ treatment increased cell shrinkage.

    In plain wordsIn cells, 5MQ treatment increased HeLa cell shrinkage.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseCell shrinkage
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Increased cell shrinkage, loss of cellular adhesions and apoptotic bodies were observed in HeLa cells after 5MQ treatment.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  3. 03LabIn vitro (cells)Efficacy outcome

    In HeLa cells, 5MQ treatment caused loss of cellular adhesions.

    In plain wordsIn cells, HeLa cells lost cellular adhesions after 5MQ treatment.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseCellular adhesion loss
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Increased cell shrinkage, loss of cellular adhesions and apoptotic bodies were observed in HeLa cells after 5MQ treatment.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  4. 04LabIn vitro (cells)Efficacy outcome

    In HeLa cells, apoptotic bodies appeared after 5MQ treatment.

    In plain wordsIn cells, HeLa cells showed apoptotic bodies after 5MQ treatment.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseApoptotic bodies
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Increased cell shrinkage, loss of cellular adhesions and apoptotic bodies were observed in HeLa cells after 5MQ treatment.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  5. 05LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment increased ZEB1 mRNA levels.

    In plain wordsIn cells, 5MQ increased ZEB1 mRNA levels in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseZEB1 mRNA
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Following treatment with 5MQ, ZEB1, SIRT1, CD16 mRNA levels were increased while TWIST and SERPIN1 mRNA levels were reduced.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  6. 06LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment increased SIRT1 mRNA levels.

    In plain wordsIn cells, 5MQ increased SIRT1 mRNA levels in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseSIRT1 mRNA
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Following treatment with 5MQ, ZEB1, SIRT1, CD16 mRNA levels were increased while TWIST and SERPIN1 mRNA levels were reduced.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  7. 07LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment increased CD16 mRNA levels.

    In plain wordsIn cells, 5MQ increased CD16 mRNA levels in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseCD16 mRNA
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Following treatment with 5MQ, ZEB1, SIRT1, CD16 mRNA levels were increased while TWIST and SERPIN1 mRNA levels were reduced.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  8. 08LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment reduced TWIST mRNA levels.

    In plain wordsIn cells, 5MQ reduced TWIST mRNA levels in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseTWIST mRNA
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Following treatment with 5MQ, ZEB1, SIRT1, CD16 mRNA levels were increased while TWIST and SERPIN1 mRNA levels were reduced.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  9. 09LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment reduced SERPIN1 mRNA levels.

    In plain wordsIn cells, 5MQ reduced SERPIN1 mRNA levels in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseSERPIN1 mRNA
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Following treatment with 5MQ, ZEB1, SIRT1, CD16 mRNA levels were increased while TWIST and SERPIN1 mRNA levels were reduced.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  10. 10LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment decreased phospho-Akt protein expression.

    In plain wordsIn cells, 5MQ decreased phospho-Akt protein expression in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    DecreasePhospho-Akt protein
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Expressions of oncogenic proteins phospho-Akt and SIRT1 were decreased.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  11. 11LabIn vitro (cells)Mechanism

    In HeLa cells, 5MQ treatment decreased SIRT1 protein expression.

    In plain wordsIn cells, 5MQ decreased SIRT1 protein expression in HeLa cells.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseSIRT1 protein
    Study

    n: not reported in source

    HeLa cervical cancer cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.1-500 μMAs given in this study.

    Source sentences

    Summary
    Expressions of oncogenic proteins phospho-Akt and SIRT1 were decreased.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.
  12. 12LabIn vitro (cells)Efficacy outcome

    In HEK-293 cells, 5MQ did not apparently affect proliferation.

    In plain wordsIn cells, 5MQ did not apparently affect HEK-293 cell proliferation.

    Peptide
    5-amino-1MQ
    Outcome
    No significant changeHEK-293 proliferation
    Study

    n: not reported in source

    HEK-293 cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    5MQ can effectively inhibit HeLa cell proliferation without apparently affecting HEK-293 cell proliferation.
    1 context sentence
    Summary · context
    0.1-500 μM of 5MQ was tested on the HeLa epithelial cervical cancer cell line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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