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Study · In vitro (cells) · rat · 2021

4 results

In vitro investigation of growth factors including MGF and IGF-1 in neural stem cell activation, proliferation, and migration.

Tunç BS, Toprak F, Toprak SF, Sozer S

Brain research16 Feb 2021Cited by 17 (Europe PMC)

PMID33607046 (opens in a new tab)DOI10.1016/j.brainres.2021.147366 (opens in a new tab)PepBankPUB-33607046
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat hippocampal neural stem cells, MGF increased neurosphere size, which suggests MGF is effective in neural progenitor cells.

    In plain wordsIn rat brain stem cells in a dish, MGF made neurospheres larger.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNeurosphere size with MGF
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neurosphere sizes were increased with MGF, signifying MGF being effective in neural progenitor cells.

Studies that did not test the peptide alone3

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 02LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In rat neural stem cells, MGF-coupled growth factor combinations failed to protect against apoptosis, unlike FGF-2 and FGF-2 coupled growth factors.

    In plain wordsIn rat brain stem cells, MGF combined with other growth factors did not protect against cell death, while FGF-2 combinations did.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeProtection against apoptosis by MGF-coupled growth factors
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells
    Comparator
    FGF-2 and FGF-2 coupled growth factors
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The apoptosis analysis revealed that FGF-2 and FGF-2 coupled growth factors effectively protect NSCs against apoptosis, whereas MGF coupled growth factors failed in this protection.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 03LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In rat neural stem cells, the growth factors tested, including MGF, moved cells from the quiescent phase to the mitosis phase, mostly without a long synthesis phase.

    In plain wordsIn rat brain stem cells, the tested growth factors, MGF among them, moved cells from rest into division.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCell cycle exit from quiescence with growth factors
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The cell cycle analysis demonstrated that these growth factors had accumulated the NSCs exit from the quiescent phase to the Mitosis phase, mostly without being long in the Synthesis Phase.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome

    In rat neural stem cells, the combination of MGF with FGF-2 was more effective in postmitotic neurons than MGF alone.

    In plain wordsIn rat brain stem cells, MGF plus FGF-2 worked better on mature neurons than MGF alone.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreasePostmitotic neurons with MGF plus FGF-2
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells
    Comparator
    MGF alone
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The combined use of MGF with FGF-2 was more effective in postmitotic neurons than MGF alone.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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