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Study · Not a test of the peptide alone · 2021

4 results

Enhanced angiogenic effects of RGD, GHK peptides and copper (II) compositions in synthetic cryogel ECM model.

Zoughaib M, Luong D, Garifullin R, Gatina DZ, Fedosimova SV, Abdullin TI

Materials science & engineering. C, Materials for biological applications21 Oct 2020Cited by 20 (Europe PMC)

PMID33545827 (opens in a new tab)DOI10.1016/j.msec.2020.111660 (opens in a new tab)PepBankPUB-33545827
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 01LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In HUVECs grown in a cryogel ECM model, the combination of RGD with GHK and Cu2+ markedly increased cell proliferation.

    In plain wordsIn lab-grown blood vessel cells, the combination of RGD, GHK and copper strongly increased cell growth.

    Peptide
    GHK-Cu
    Outcome
    IncreaseHUVEC proliferation
    Study

    humann: not reported in source

    HUVECs in pHEMA cryogel ECM model
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    The results demonstrate that the combination of RGD with GHK and further with Cu2+ dramatically increases cell proliferation, differentiation, and production of a series of angiogenesis related cytokines and growth factors.
    1 context sentence
    Summary · context
    Angiogenic responses of HUVECs grown within the cryogel ECM model were analyzed.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 02LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In HUVECs grown in a cryogel ECM model, the combination of RGD with GHK and Cu2+ markedly increased cell differentiation.

    In plain wordsIn lab-grown blood vessel cells, the combination of RGD, GHK and copper strongly increased cell maturation.

    Peptide
    GHK-Cu
    Outcome
    IncreaseHUVEC differentiation
    Study

    humann: not reported in source

    HUVECs in pHEMA cryogel ECM model
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    The results demonstrate that the combination of RGD with GHK and further with Cu2+ dramatically increases cell proliferation, differentiation, and production of a series of angiogenesis related cytokines and growth factors.
    1 context sentence
    Summary · context
    Angiogenic responses of HUVECs grown within the cryogel ECM model were analyzed.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  3. 03LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In HUVECs grown in a cryogel ECM model, the combination of RGD with GHK and Cu2+ markedly increased production of angiogenesis related cytokines and growth factors.

    In plain wordsIn lab-grown blood vessel cells, the combination of RGD, GHK and copper strongly increased growth signals made by the cells.

    Peptide
    GHK-Cu
    Outcome
    IncreaseProduction of angiogenesis related cytokines and growth factors
    Study

    humann: not reported in source

    HUVECs in pHEMA cryogel ECM model
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    The results demonstrate that the combination of RGD with GHK and further with Cu2+ dramatically increases cell proliferation, differentiation, and production of a series of angiogenesis related cytokines and growth factors.
    1 context sentence
    Summary · context
    Angiogenic responses of HUVECs grown within the cryogel ECM model were analyzed.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  4. 04LabNot a test of GHK-Cu aloneIn vitro (cells)Mechanism

    In HUVECs in the cryogel ECM model, the glutathione level was altered in relation to the angiogenic effects; the direction is not stated.

    In plain wordsIn lab-grown blood vessel cells, the level of the antioxidant glutathione changed, but the abstract does not say in which direction.

    Peptide
    GHK-Cu
    Outcome
    Direction not reportedGlutathione level
    Study

    humann: not reported in source

    HUVECs in pHEMA cryogel ECM model
    Outcome group
    Oxidative stress · Cardiovascular

    Source sentences

    Summary
    Furthermore, the level of glutathione, a key cellular antioxidant and redox regulator, was altered in relation to the angiogenic effects.
    1 context sentence
    Summary · context
    Angiogenic responses of HUVECs grown within the cryogel ECM model were analyzed.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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