Skip to content

Study · Animal study (in vivo) · mouse · 2021

3 results

Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism.

Kang GM, Min SH, Lee CH, Kim JY, Lim HS, Choi MJ, Jung SB, Park JW, Kim S, Park CB, Dugu H, Choi JH and 10 more

Show all authors

Jang WH, Park SE, Cho YM, Kim JG, Kim KG, Choi CS, Kim YB, Lee C, Shong M, Kim MS

Cell metabolism1 Feb 2021Cited by 82 (Europe PMC)

PMID33535098 (opens in a new tab)PMCIDPMC7959183 (opens in a new tab)DOI10.1016/j.cmet.2021.01.003 (opens in a new tab)PepBankPUB-33535098
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, central administration of MOTS‑c recapitulated the adipose phenotype of Crif1 heterodeficient mice.

    In plain wordsIn mice, MOTS‑c given into the brain reproduced the fat tissue changes seen in mice with mild mitochondrial stress.

    Peptide
    MOTS-c
    Outcome
    Not applicableAdipose phenotype after central MOTS-c
    Study

    mousen: not reported in source

    Mice (central administration)
    Outcome group
    Mitochondrial function · Metabolic and weight
    Studied dose
    Dose not stated · centralAs given in this study (mouse).

    Source sentences

    Summary
    Central administration of MOTS-c or β-END recapitulates the adipose phenotype of Crif1 heterodeficient mice, suggesting these factors as potential mediators.
    1 context sentence
    Summary · context
    These metabolic benefits are mediated by enhanced thermogenesis and mitochondrial unfolded protein responses (UPRmt) in distal adipose tissues.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, partial Crif1 deficiency in POMC neurons increased the expression of the body's own MOTS‑c.

    In plain wordsIn mice, mild mitochondrial stress in a set of brain neurons raised the body's own MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    IncreaseMOTS-c expression in POMC neurons with Crif1 deficiency
    Study

    mousen: not reported in source

    Mice with partial Crif1 deficiency in POMC neurons
    Outcome group
    Mitochondrial function · Metabolic and weight

    Source sentences

    Summary
    In POMC neurons, partial Crif1 deficiency increases the expression of β-endorphin (β-END) and mitochondrial DNA-encoded peptide MOTS-c.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, regular running exercise at moderate intensity stimulated hypothalamic expression of the body's own MOTS‑c.

    In plain wordsIn mice, regular moderate running raised the body's own MOTS‑c in the hypothalamus of the brain.

    Peptide
    MOTS-c
    Outcome
    IncreaseHypothalamic MOTS-c expression after running
    Study

    mousen: not reported in source

    Regular running exercise in mice
    Outcome group
    Exercise and physical function · Metabolic and weight

    Source sentences

    Summary
    Consistently, regular running exercise at moderate intensity stimulates hypothalamic MOTS-c/β-END expression and induces adipose tissue UPRmt and thermogenesis.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.