EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON "AGED" HETEROCHROMATIN.

Lezhava T, Jokhadze T, Monaselidze J, Buadze T, Gaiozishvili M, Sigua T

Georgian medical news1 Dec 2020

PMID33526740PepBankPUB-33526740

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

01LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In cultured lymphocytes, a pool of four peptide bioregulators including Epitalon induced deheterochromatinization of total heterochromatin.
In plain wordsIn lab-grown lymphocytes, a group of four short peptides, including Epitalon, loosened condensed chromatin.
Peptide
Epitalon
Outcome
DecreaseTotal heterochromatin
Study
humann: not reported in source
Cultured lymphocytes from individuals aged 75-88 and 20-40 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
The results showed that peptide bioregulators: 1. induce unrolling - deheterochromatinization of total heterochromatin
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (tetrapeptides: Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala; Ala-Glu-Asp-Pro and dipeptide - Lys-Glu) on total heterochromatin, constitutive (structural) and facultative heterochromatin in cultured lymphocytes of individuals aged 75-88 and 20 - 40 years have been studied.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3352674001
02LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In cultured lymphocytes, a pool of four peptide bioregulators including Epitalon induced deheterochromatinization of constitutive heterochromatin.
In plain wordsIn lab-grown lymphocytes, a group of four short peptides, including Epitalon, loosened one type of condensed chromatin.
Peptide
Epitalon
Outcome
DecreaseConstitutive heterochromatin
Study
humann: not reported in source
Cultured lymphocytes from individuals aged 75-88 and 20-40 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
constitutive (pericentromeric, telomeric, and nucleolar organizer regions (NOR))
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (tetrapeptides: Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala; Ala-Glu-Asp-Pro and dipeptide - Lys-Glu) on total heterochromatin, constitutive (structural) and facultative heterochromatin in cultured lymphocytes of individuals aged 75-88 and 20 - 40 years have been studied.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3352674002
03LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In cultured lymphocytes, a pool of four peptide bioregulators including Epitalon induced deheterochromatinization of facultative heterochromatin.
In plain wordsIn lab-grown lymphocytes, a group of four short peptides, including Epitalon, loosened another type of condensed chromatin.
Peptide
Epitalon
Outcome
DecreaseFacultative heterochromatin
Study
humann: not reported in source
Cultured lymphocytes from individuals aged 75-88 and 20-40 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
induce unrolling - deheterochromatinization of total heterochromatin, constitutive (pericentromeric, telomeric, and nucleolar organizer regions (NOR)) and facultative heterochromatin
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (tetrapeptides: Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala; Ala-Glu-Asp-Pro and dipeptide - Lys-Glu) on total heterochromatin, constitutive (structural) and facultative heterochromatin in cultured lymphocytes of individuals aged 75-88 and 20 - 40 years have been studied.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3352674003
04LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In cultured lymphocytes, a pool of four peptide bioregulators including Epitalon induced a higher level of sister chromatid exchanges in telomeric heterochromatin.
In plain wordsIn lab-grown lymphocytes, a group of four short peptides, including Epitalon, raised chromosome exchange in telomere regions.
Peptide
Epitalon
Outcome
IncreaseSCE level in telomeric heterochromatin
Study
humann: not reported in source
Cultured lymphocytes from individuals aged 75-88 and 20-40 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
induce higher level of SCEs (deheterochromatinization), were registered in telomeric heterochromatin
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (tetrapeptides: Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala; Ala-Glu-Asp-Pro and dipeptide - Lys-Glu) on total heterochromatin, constitutive (structural) and facultative heterochromatin in cultured lymphocytes of individuals aged 75-88 and 20 - 40 years have been studied.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3352674004
05LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In cultured lymphocytes, a pool of four peptide bioregulators including Epitalon decreased the sister chromatid exchange level in the medial regions of chromosome arms.
In plain wordsIn lab-grown lymphocytes, a group of four short peptides, including Epitalon, lowered chromosome exchange in middle arm regions.
Peptide
Epitalon
Outcome
DecreaseSCE level in medial regions of chromosome arms
Study
humann: not reported in source
Cultured lymphocytes from individuals aged 75-88 and 20-40 years
Outcome group
Aging markers · Aging and longevity
Source sentences
Summary
decreased (heterochromatinization) SCEs level in the medial regions of chromosome arms
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of synthetic peptide bioregulators (tetrapeptides: Ala-Glu-Asp-Gly; Lys-Glu-Asp-Ala; Ala-Glu-Asp-Pro and dipeptide - Lys-Glu) on total heterochromatin, constitutive (structural) and facultative heterochromatin in cultured lymphocytes of individuals aged 75-88 and 20 - 40 years have been studied.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3352674005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 5 to 11Current
28 Oct 2026, 02:02 UTC
The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.
Study results updated
Versions 3 to 4
21 Oct 2026, 16:35 UTC
The same notice was added 2 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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