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Study · Animal study (in vivo) · sheep · 2021

15 results

IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus.

Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD

American journal of physiology. Endocrinology and metabolism11 Jan 2021Cited by 24 (Europe PMC)

PMID33427051 (opens in a new tab)PMCIDPMC7988781 (opens in a new tab)DOI10.1152/ajpendo.00453.2020 (opens in a new tab)PepBankPUB-33427051
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, a 1-week LR3 IGF-1 infusion did not significantly change total fetal weight versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 did not clearly change total fetal weight compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeFetal weight
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Measurements

    Fetal weight
    3.682 kg
    LR3 IGF-1
    Fetal weight
    3.26 kg
    saline

    Source sentences

    Summary
    By the end of the infusion, fetal weights were not statistically different between groups (SAL: 3.260 ± 0.211 kg, LR3 IGF-1: 3.682 ± 0.183; P = 0.15).
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, LR3 IGF-1 infusion increased fetal heart weight versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 increased heart weight compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFetal heart weight
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Body composition · Cardiovascular
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Fetal heart, adrenal gland, and spleen weights were higher
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, LR3 IGF-1 infusion increased fetal adrenal gland weight versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 increased adrenal gland weight compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFetal adrenal gland weight
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Body composition · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Fetal heart, adrenal gland, and spleen weights were higher
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, LR3 IGF-1 infusion increased fetal spleen weight versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 increased spleen weight compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFetal spleen weight
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Body composition · Immune and inflammation
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Fetal heart, adrenal gland, and spleen weights were higher
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, LR3 IGF-1 infusion lowered fetal insulin concentrations versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 lowered insulin levels compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFetal insulin concentration
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    and insulin was lower in LR3 IGF-1 (P < 0.05).
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, uterine blood flow was similar with LR3 IGF-1 and saline.

    In plain wordsIn fetal sheep, blood flow to the uterus was similar with LR3 IGF-1 and saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeUterine blood flow
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Pregnancy and fetal development · Cardiovascular
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Uterine and umbilical blood flow and umbilical uptake rates of glucose, lactate, and oxygen were similar between groups.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, umbilical blood flow was similar with LR3 IGF-1 and saline.

    In plain wordsIn fetal sheep, umbilical blood flow was similar with LR3 IGF-1 and saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeUmbilical blood flow
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Pregnancy and fetal development · Cardiovascular
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Uterine and umbilical blood flow and umbilical uptake rates of glucose, lactate, and oxygen were similar between groups.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, the umbilical uptake rate of glucose was similar with LR3 IGF-1 and saline.

    In plain wordsIn fetal sheep, glucose uptake through the umbilical cord was similar with LR3 IGF-1 and saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeUmbilical glucose uptake rate
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Pregnancy and fetal development · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Uterine and umbilical blood flow and umbilical uptake rates of glucose, lactate, and oxygen were similar between groups.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, the umbilical uptake rate of lactate was similar with LR3 IGF-1 and saline.

    In plain wordsIn fetal sheep, lactate uptake through the umbilical cord was similar with LR3 IGF-1 and saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeUmbilical lactate uptake rate
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Pregnancy and fetal development · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Uterine and umbilical blood flow and umbilical uptake rates of glucose, lactate, and oxygen were similar between groups.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, the umbilical uptake rate of oxygen was similar with LR3 IGF-1 and saline.

    In plain wordsIn fetal sheep, oxygen uptake through the umbilical cord was similar with LR3 IGF-1 and saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeUmbilical oxygen uptake rate
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Pregnancy and fetal development · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Uterine and umbilical blood flow and umbilical uptake rates of glucose, lactate, and oxygen were similar between groups.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, LR3 IGF-1 infusion lowered umbilical amino acid uptake rates versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 lowered amino acid uptake through the umbilical cord compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseUmbilical amino acid uptake rate
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Umbilical amino acid uptake rates were lower in LR3 IGF-1 (P < 0.05)
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, LR3 IGF-1 infusion lowered fetal concentrations of multiple amino acids versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 lowered the levels of several amino acids compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFetal amino acid concentrations
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    as were fetal concentrations of multiple amino acids.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, fetal protein kinetic rates were similar with LR3 IGF-1 and saline.

    In plain wordsIn fetal sheep, protein turnover rates were similar with LR3 IGF-1 and saline.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeFetal protein kinetic rates
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Protein and amino acid metabolism · Metabolic and weight
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    Fetal protein kinetic rates were similar.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In late gestation fetal sheep, LR3 IGF-1 infusion increased myoblast proliferation in skeletal muscle versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 increased muscle precursor cell growth compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseSkeletal muscle myoblast proliferation
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    LR3 IGF-1 skeletal muscle had higher myoblast proliferation (P < 0.05).
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In late gestation fetal sheep, LR3 IGF-1 infusion lowered fetal oxygen content versus saline.

    In plain wordsIn fetal sheep, LR3 IGF-1 lowered the oxygen content of fetal blood compared with saline.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseFetal oxygen content
    Study

    sheepn = 16

    Late gestation fetal sheep
    Comparator
    Saline
    Outcome group
    Pregnancy and fetal development · Whole body
    Studied dose
    Dose not stated · intravenous · 1 weekAs given in this study (sheep).

    Source sentences

    Summary
    lower fetal oxygen content; however, LR-3 IGF-1-treated fetuses were still able to effectively utilize the available nutrients and oxygen to support organ growth and myoblast proliferation.
    1 context sentence
    Summary · context
    Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n = 8) for 1 wk.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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