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Study · Measured the body's own peptide · 2021

5 results

Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea.

Baylan FA, Yarar E

Sleep & breathing = Schlaf & Atmung4 Jan 2021Cited by 17 (Europe PMC)

PMID33394327 (opens in a new tab)DOI10.1007/s11325-020-02273-0 (opens in a new tab)PepBankPUB-33394327
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In adults, serum MOTS‑C levels were significantly lower in patients with obstructive sleep apnea than in healthy controls.

    In plain wordsIn adults, the body's own MOTS‑c level in blood was lower in people with sleep apnea than in healthy people.

    Peptide
    MOTS-c
    Outcome
    DecreaseSerum MOTS-C in OSA versus healthy controls
    Study

    n = 90

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    MOTS-C levels were significantly lower in patients with OSA compared to healthy controls (p < 0.000)
    1 context sentence
    Summary · context
    Seventy patients with OSAS and 20 healthy controls were included.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Serum MOTS‑C levels decreased as OSA severity increased.

    In plain wordsThe body's own MOTS‑c level in blood was lower the more severe the sleep apnea was.

    Peptide
    MOTS-c
    Outcome
    DecreaseSerum MOTS-C by OSA severity
    Study

    n = 90

    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    we found that MOTS-C levels decreased as OSA severity increased.
    1 context sentence
    Summary · context
    Seventy patients with OSAS and 20 healthy controls were included.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Serum MOTS‑C levels correlated negatively with the apnea-hypopnea index (AHI).

    In plain wordsThe body's own MOTS‑c level in blood was lower when sleep apnea was more severe, as measured by the apnea index.

    Peptide
    MOTS-c
    Outcome
    DecreaseCorrelation of serum MOTS-C with AHI
    Study

    n = 90

    Outcome group
    Endogenous peptide levels · Respiratory

    Measurements

    correlation coefficient r
    −0.492 r
    AHI

    Source sentences

    Summary
    There was a negative correlation between serum MOTS-C levels and AHI and BMI (r = - 0.492, p < 0.001, r = - 0.382, p < 0.001, respectively).
    1 context sentence
    Summary · context
    Seventy patients with OSAS and 20 healthy controls were included.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Serum MOTS‑C levels correlated negatively with body mass index (BMI).

    In plain wordsThe body's own MOTS‑c level in blood was lower in people with a higher body mass index.

    Peptide
    MOTS-c
    Outcome
    DecreaseCorrelation of serum MOTS-C with BMI
    Study

    n = 90

    Outcome group
    Body weight · Metabolic and weight

    Measurements

    correlation coefficient r
    −0.382 r
    BMI

    Source sentences

    Summary
    There was a negative correlation between serum MOTS-C levels and AHI and BMI (r = - 0.492, p < 0.001, r = - 0.382, p < 0.001, respectively).
    1 context sentence
    Summary · context
    Seventy patients with OSAS and 20 healthy controls were included.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In linear regression analysis with BMI and HOMA-IR in the model, serum MOTS‑C levels were independently associated with AHI.

    In plain wordsThe body's own MOTS‑c level in blood stayed linked to sleep apnea severity after adjusting for body mass index and insulin resistance.

    Peptide
    MOTS-c
    Outcome
    Not applicableIndependent association of serum MOTS-C with AHI in regression
    Study

    n = 90

    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    Serum MOTS-C levels were independently associated with AHI in BMI and HOMA-IR in linear regression analysis (p < 0.010, p < 0.007, p < 0.007, respectively).
    1 context sentence
    Summary · context
    Seventy patients with OSAS and 20 healthy controls were included.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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