Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats.

Sato C, Miyakoshi N, Kasukawa Y, Nozaka K, Tsuchie H, Nagahata I, Yuasa Y, Abe K, Saito H, Shoji R, Shimada Y

Journal of bone and mineral metabolism3 Jan 2021Cited by 30 (Europe PMC)

PMID33392725DOI10.1007/s00774-020-01184-0PepBankPUB-33392725

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, teriparatide improved BMD compared with vehicle control.
In plain wordsIn rats with ovariectomy and tail suspension, teriparatide improved bone density compared with vehicle control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone mineral density
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Comparator
vehicle without exercise
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 µg/kg, 3 days/week · 1 and 8 weeksAs given in this study (Wistar rat).
Source sentences
Summary
TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
Report a problemFND-3339272501
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, teriparatide improved bone structure compared with vehicle control.
In plain wordsIn rats with ovariectomy and tail suspension, teriparatide improved bone structure compared with vehicle control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone structure
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Comparator
vehicle without exercise
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 µg/kg, 3 days/week · 1 and 8 weeksAs given in this study (Wistar rat).
Source sentences
Summary
TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
Report a problemFND-3339272502
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, teriparatide improved femoral metaphysis bone strength compared with vehicle control.
In plain wordsIn rats with ovariectomy and tail suspension, teriparatide improved femoral metaphysis strength compared with vehicle control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral metaphysis bone strength
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Comparator
vehicle without exercise
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 µg/kg, 3 days/week · 1 and 8 weeksAs given in this study (Wistar rat).
Source sentences
Summary
TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
Report a problemFND-3339272503
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, teriparatide increased percentage skeletal muscle mass compared with vehicle control.
In plain wordsIn rats with ovariectomy and tail suspension, teriparatide increased muscle mass percentage compared with vehicle control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePercentage skeletal muscle mass
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Comparator
vehicle without exercise
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
30 µg/kg, 3 days/week · 1 and 8 weeksAs given in this study (Wistar rat).
Source sentences
Summary
TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
Report a problemFND-3339272504
05AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, teriparatide decreased percentage fat mass compared with vehicle control.
In plain wordsIn rats with ovariectomy and tail suspension, teriparatide decreased fat mass percentage compared with vehicle control.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreasePercentage fat mass
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Comparator
vehicle without exercise
Outcome group
Body weight · Metabolic and weight
Studied dose
30 µg/kg, 3 days/week · 1 and 8 weeksAs given in this study (Wistar rat).
Source sentences
Summary
TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
Report a problemFND-3339272505
06AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, teriparatide decreased bone marrow adipose volume compared with vehicle control.
In plain wordsIn rats with ovariectomy and tail suspension, teriparatide decreased bone marrow fat volume compared with vehicle control.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseBone marrow adipose volume
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Comparator
vehicle without exercise
Outcome group
Body composition · Musculoskeletal
Studied dose
30 µg/kg, 3 days/week · 1 and 8 weeksAs given in this study (Wistar rat).
Source sentences
Summary
TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
Report a problemFND-3339272506

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized and tail-suspended rats, combined teriparatide and exercise significantly affected femoral diaphysis BMD, bone structure, and cortical bone strength.
In plain wordsIn rats with ovariectomy and tail suspension, combined teriparatide and exercise significantly affected femoral shaft bone density, structure, and strength.
Peptide
Teriparatide (PTH 1-34)
Outcome
Direction not reportedFemoral diaphysis bone parameters with combined treatment
Study
Wistar ratn: not reported in source
ovariectomized and tail-suspended female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Furthermore, combined treatment significantly affected BMD, bone structure, and bone strength of cortical bone at the femoral diaphysis.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-3339272507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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