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Study · Randomized controlled trial · n = 200 · 2021

5 results

Intrinsic, dynamic and effective connectivity among large-scale brain networks modulated by oxytocin.

Jiang X, Ma X, Geng Y, Zhao Z, Zhou F, Zhao W, Yao S, Yang S, Zhao Z, Becker B, Kendrick KM

NeuroImage24 Dec 2020Cited by 35 (Europe PMC)

PMID33359350 (opens in a new tab)DOI10.1016/j.neuroimage.2020.117668 (opens in a new tab)PepBankPUB-33359350
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy subjects, oxytocin did not significantly change temporal state characteristics (switching frequency, transition probability, dwell time) of resting-state brain networks.

    In plain wordsIn healthy people, oxytocin did not change how brain network activity patterns switched over time.

    Peptide
    Oxytocin
    Outcome
    No significant changeTemporal state characteristics of brain networks
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Results showed that while no significant effects of oxytocin were found on brain temporal state related characteristics (including temporal state switching frequency, probability of transitions between neighboring states, and averaged dwell time on each state)
    1 context sentence
    Summary · context
    The present study employed a novel computational framework to investigate these latter aspects in 15 oxytocin-sensitive regions using data from randomized placebo-controlled between-subject resting state functional MRI studies incorporating 200 healthy subjects.
  2. 02HumanRandomized controlled trialMechanism

    In healthy subjects, oxytocin modulated effective connectivity among 15 brain regions (54 links), mainly by increasing it within and between emotion, reward, salience, attention and social cognition networks.

    In plain wordsIn healthy people, oxytocin changed how brain regions influence each other, mostly by increasing connectivity between networks for emotion, reward and social thinking.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffective connectivity among 15 oxytocin-sensitive regions
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    oxytocin extensively (n = 54 links) modulated effective connectivity among the 15 regions.
    2 context sentences
    Summary · context
    The effects of oxytocin were primarily characterized by increased effective connectivity both between and within emotion, reward, salience, attention and social cognition processing networks and their interactions with the default mode network.
    Summary · context
    The present study employed a novel computational framework to investigate these latter aspects in 15 oxytocin-sensitive regions using data from randomized placebo-controlled between-subject resting state functional MRI studies incorporating 200 healthy subjects.
  3. 03HumanRandomized controlled trialMechanism

    In healthy subjects, oxytocin particularly affected top-down control over emotional processing regions such as the amygdala.

    In plain wordsIn healthy people, oxytocin particularly affected top-down brain control over emotion regions such as the amygdala.

    Peptide
    Oxytocin
    Outcome
    Not applicableTop-down effective connectivity to emotional processing regions such as amygdala
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Top-down control over emotional processing regions such as the amygdala was particularly affected.
    1 context sentence
    Summary · context
    The present study employed a novel computational framework to investigate these latter aspects in 15 oxytocin-sensitive regions using data from randomized placebo-controlled between-subject resting state functional MRI studies incorporating 200 healthy subjects.
  4. 04HumanRandomized controlled trialMechanism

    In healthy subjects, oxytocin increased effective homotopic interhemispheric connectivity in almost all of the studied regions.

    In plain wordsIn healthy people, oxytocin increased connectivity between matching regions of the two brain halves.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffective homotopic interhemispheric connectivity
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin also increased effective homotopic interhemispheric connectivity in almost all these regions.
    1 context sentence
    Summary · context
    The present study employed a novel computational framework to investigate these latter aspects in 15 oxytocin-sensitive regions using data from randomized placebo-controlled between-subject resting state functional MRI studies incorporating 200 healthy subjects.
  5. 05HumanRandomized controlled trialMechanism

    In healthy subjects, oxytocin effects on effective connectivity were sex-dependent and more extensive in males.

    In plain wordsIn healthy people, oxytocin changed brain connectivity more widely in men than in women.

    Peptide
    Oxytocin
    Outcome
    Not applicableSex-dependence of oxytocin effects on effective connectivity
    Study

    n = 200

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, the effects of oxytocin on effective connectivity were sex-dependent, being more extensive in males.
    1 context sentence
    Summary · context
    The present study employed a novel computational framework to investigate these latter aspects in 15 oxytocin-sensitive regions using data from randomized placebo-controlled between-subject resting state functional MRI studies incorporating 200 healthy subjects.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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