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Study · In vitro (cells) · 2020

4 results

[The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.]

Ivko OM, Drobintseva AO, Leont'eva DO, Kvetnoy IM, Polyakova VO, Linkova NS

Advances in gerontology = Uspekhi gerontologii1 Jan 2020

PMID33342107 (opens in a new tab)PepBankPUB-33342107
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In senescent human pineal gland cell cultures, AEDG (epitalon) increased the area of MitoTracker Red mitochondrial staining 1,5 times.

    In plain wordsIn cells from the human pineal gland, AEDG increased mitochondrial staining in aging cell cultures.

    Peptide
    Epitalon
    Outcome
    IncreaseMitoTracker Red mitochondrial staining area
    Study

    humann: not reported in source

    Senescent human pineal gland cell culture
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AEDG peptide increases in 1,5 times the square of MitoTracker Red mitochondries staining
  2. 02LabIn vitro (cells)Mechanism

    In senescent human pineal gland cell cultures, AEDG (epitalon) decreased the expression of ribosomal protein L7A by 22%.

    In plain wordsIn cells from the human pineal gland, AEDG lowered a ribosomal protein level in aging cell cultures.

    Peptide
    Epitalon
    Outcome
    DecreaseRibosomal protein L7A expression
    Study

    humann: not reported in source

    Senescent human pineal gland cell culture
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Measurements

    L7A expression change
    22%
    decrease, pineal cells

    Source sentences

    Summary
    and decreases on 22% the expression of ribosomal protein L7A in cultures of human pineal gland cells during its senescence.
  3. 03LabIn vitro (cells)Mechanism

    In senescent human thymic cell cultures, KE increased MitoTracker Red mitochondrial staining area by 1,5 times.

    In plain wordsIn cells from the human thymus, KE increased mitochondrial staining during aging.

    Peptide
    Vilon (KE)
    Outcome
    IncreaseMitoTracker Red staining area
    Study

    humann: not reported in source

    Senescent human thymic cell cultures
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated

    Measurements

    MitoTracker Red staining area
    1.5 times
    KE-treated senescent human thymic cells

    Source sentences

    Summary
    KE peptide increases in 1,5 times the square of MitoTracker Red mitochondries staining and decreases on 15% the expression of ribosomal protein L7A in cultures of human thymic cells during its senescence.
    1 context sentence
    Summary · context
    It was verified new molecular targets of geroprotective activity of AEDG (epitalon) and KE (vilon) peptides by the method of confocal laser scanning microscopy.
  4. 04LabIn vitro (cells)Mechanism

    In senescent human thymic cell cultures, KE decreased L7A ribosomal protein expression by 15%.

    In plain wordsIn cells from the human thymus, KE reduced L7A protein expression during aging.

    Peptide
    Vilon (KE)
    Outcome
    DecreaseL7A ribosomal protein expression
    Study

    humann: not reported in source

    Senescent human thymic cell cultures
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Measurements

    L7A expression decrease
    15%
    KE-treated senescent human thymic cells

    Source sentences

    Summary
    KE peptide increases in 1,5 times the square of MitoTracker Red mitochondries staining and decreases on 15% the expression of ribosomal protein L7A in cultures of human thymic cells during its senescence.
    1 context sentence
    Summary · context
    It was verified new molecular targets of geroprotective activity of AEDG (epitalon) and KE (vilon) peptides by the method of confocal laser scanning microscopy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 10Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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