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Study · Randomized controlled trial · n = 26 · 2021

2 results

Preliminary evidence that oxytocin does not improve mentalizing in women with schizophrenia.

Bradley ER, Tai M, Hankin M, Woolley JD

Hormones and behavior28 Dec 2020Cited by 9 (Europe PMC)

PMID33340522 (opens in a new tab)PMCIDPMC7854492 (opens in a new tab)DOI10.1016/j.yhbeh.2020.104915 (opens in a new tab)PepBankPUB-33340522
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In exploratory analyses of women with schizophrenia, higher anti-dopaminergic medication dosage was associated with a decreased response to oxytocin.

    In plain wordsIn women with schizophrenia, higher doses of anti-dopaminergic medication were linked to a weaker response to oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableAssociation of anti-dopaminergic medication dosage with response to oxytocin
    Study

    n: not reported in source

    Analysis
    Exploratory
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    40 IU · single doseAs given in this study (human).

    Source sentences

    Summary
    Exploratory analyses showed that higher anti-dopaminergic medication dosage was associated with a decreased response to oxytocin, consistent with previous findings in men.
    1 context sentence
    Summary · context
    We tested the effects of a single-dose oxytocin challenge (40 IU) on mentalizing task performance among 26 women with schizophrenia and 38 healthy control women using a randomized, placebo-controlled, double-blind, crossover design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with schizophrenia, a single 40 IU dose of oxytocin did not improve mentalizing compared with placebo.

    In plain wordsIn women with schizophrenia, a single oxytocin dose did not improve mentalizing compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeMentalizing task performance
    Study

    n = 26

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    40 IU · single doseAs given in this study (human).

    Source sentences

    Summary
    In contrast to our previous finding in a male sample, oxytocin did not improve mentalizing in this sample of women with schizophrenia.
    1 context sentence
    Summary · context
    We tested the effects of a single-dose oxytocin challenge (40 IU) on mentalizing task performance among 26 women with schizophrenia and 38 healthy control women using a randomized, placebo-controlled, double-blind, crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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