Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration.

Zou Z, Wang L, Zhou Z, Sun Q, Liu D, Chen Y, Hu H, Cai Y, Lin S, Yu Z, Tan B, Guo W, Ling Z, Zou X

Bioactive materials7 Dec 2020Cited by 83 (Europe PMC)

PMID33336115PMCIDPMC7723774DOI10.1016/j.bioactmat.2020.11.021PepBankPUB-33336115

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with cranial defects, hydrogel containing nHAP and PTH(1-34) promoted bone regeneration compared with hydrogel containing nHAP.
In plain wordsIn rats with skull defects, hydrogel containing nHAP and PTH(1-34) improved bone regeneration compared with hydrogel containing nHAP.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCranial bone regeneration versus nHAP hydrogel
Study
ratn: not reported in source
rat cranial defect
Comparator
hydrogel with nHAP
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · implantationAs given in this study (rat).
Source sentences
Summary
Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP, indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.
Report a problemFND-3333611507
02LabIn vitro (cells)Efficacy outcome
In BMSCs, increasing PTH(1-34) content in hydrogels enhanced osteogenic differentiation.
In plain wordsIn lab tests, increasing PTH(1-34) content in hydrogels increased bone-forming differentiation compared with lower content.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePTH-content-dependent osteogenic differentiation
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells
Comparator
lower PTH(1-34) hydrogel content
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
We found that increasing the content of PTH(1-34) in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs.
Report a problemFND-3333611505

Studies that did not test the peptide alone5

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

03AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats with cranial defects, hydrogel containing nHAP and PTH(1-34) promoted bone regeneration compared with hydrogel alone.
In plain wordsIn rats with skull defects, hydrogel containing nHAP and PTH(1-34) improved bone regeneration compared with hydrogel alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCranial bone regeneration versus hydrogel
Study
ratn: not reported in source
rat cranial defect
Comparator
hydrogel alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP, indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-3333611506
04LabNot a test of Teriparatide (PTH 1-34) aloneIn vitro (cells)Safety outcome
In rat bone marrow mesenchymal stem-cell experiments, hydrogel containing nHAP and PTH(1-34) showed strong biocompatibility.
In plain wordsIn lab tests with rat bone marrow cells, hydrogel containing nHAP and PTH(1-34) showed strong biocompatibility.
Peptide
Teriparatide (PTH 1-34)
Outcome
Not applicableBiocompatibility
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells
Outcome group
Adverse events · Musculoskeletal
Source sentences
Summary
In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34) exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) via the Notch signaling pathway, as shown by the upregulated expression of osteogenic-related proteins.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-3333611502
05LabNot a test of Teriparatide (PTH 1-34) aloneIn vitro (cells)Efficacy outcome
In rat bone marrow mesenchymal stem cells, hydrogel containing nHAP and PTH(1-34) facilitated osteogenic differentiation via Notch signaling.
In plain wordsIn rat cells, hydrogel containing nHAP and PTH(1-34) promoted development into bone-forming cells through Notch signaling.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteogenic differentiation
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34) exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) via the Notch signaling pathway, as shown by the upregulated expression of osteogenic-related proteins.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-3333611503
06LabNot a test of Teriparatide (PTH 1-34) aloneIn vitro (cells)Mechanism
In rat bone marrow mesenchymal stem cells, hydrogel containing nHAP and PTH(1-34) increased osteogenic-related protein expression.
In plain wordsIn rat cells, hydrogel containing nHAP and PTH(1-34) increased proteins associated with bone formation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteogenic-related protein expression
Study
ratn: not reported in source
rat bone marrow mesenchymal stem cells
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34) exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) via the Notch signaling pathway, as shown by the upregulated expression of osteogenic-related proteins.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-3333611504
07LabNot a test of Teriparatide (PTH 1-34) aloneIn vitro (cell-free)Activity measurement
In hydrogel tests, mechanical properties were almost maintained after adding nHAP and PTH(1-34).
In plain wordsIn lab tests, hydrogel mechanical properties were almost unchanged after adding nHAP and PTH(1-34).
Peptide
Teriparatide (PTH 1-34)
Outcome
Direction not reportedHydrogel mechanical properties
Study
n: not reported in source
chitosan/alginate hydrogels
Comparator
hydrogel before nHAP and PTH(1-34) addition
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-3333611501

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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