Skip to content

Study · Non-randomized trial · n = 12 · 2021

7 results

Intranasal oxytocin has sympathoexcitatory effects on vascular tone in healthy males.

Meusel M, Herrmann M, Machleidt F, Franzen K, Vonthein R, Sayk F

American journal of physiology. Regulatory, integrative and comparative physiology9 Dec 2020Cited by 4 (Europe PMC)

PMID33296278 (opens in a new tab)DOI10.1152/ajpregu.00062.2020 (opens in a new tab)PepBankPUB-33296278
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin increased resting MSNA burst rate versus placebo.

    In plain wordsIn healthy men, nasal oxytocin increased resting sympathetic nerve activity compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseResting muscle sympathetic nerve activity (burst rate)
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Measurements

    MSNA burst rate net increase
    4.3 bursts/min
    oxytocin
    MSNA burst rate net increase
    2.2 bursts/min
    placebo

    Source sentences

    Summary
    After oxytocin, resting MSNA (burst rate and total activity) showed significant net increases from pre to postsubstance II compared with placebo [Δincrease = +4.3 ± 1.2 (oxytocin) vs. +2.2 ± 1.4 bursts/min (placebo), ANOVA; P < 0.05; total activity = 184 ± 11.5% (oxytocin) vs. 121 ± 14.3% (pl…
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin increased resting MSNA total activity versus placebo.

    In plain wordsIn healthy men, nasal oxytocin increased total resting sympathetic nerve activity compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseResting muscle sympathetic nerve activity (total activity)
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Measurements

    MSNA total activity
    184%
    oxytocin
    MSNA total activity
    121%
    placebo

    Source sentences

    Summary
    After oxytocin, resting MSNA (burst rate and total activity) showed significant net increases from pre to postsubstance II compared with placebo [Δincrease = +4.3 ± 1.2 (oxytocin) vs. +2.2 ± 1.4 bursts/min (placebo), ANOVA; P < 0.05; total activity = 184 ± 11.5% (oxytocin) vs. 121 ± 14.3% (pl…
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin produced a small but significant net increase in resting diastolic blood pressure versus placebo.

    In plain wordsIn healthy men, nasal oxytocin slightly raised diastolic blood pressure at rest compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseResting diastolic blood pressure
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This was combined with a small but significant net increase in resting diastolic BP
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin did not alter systolic blood pressure.

    In plain wordsIn healthy men, nasal oxytocin did not change systolic blood pressure.

    Peptide
    Oxytocin
    Outcome
    No significant changeSystolic blood pressure
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This was combined with a small but significant net increase in resting diastolic BP, whereas systolic and mean arterial BP or HR as well as baroreflex sensitivity at vasoactive drug challenge were not altered.
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin did not alter mean arterial blood pressure.

    In plain wordsIn healthy men, nasal oxytocin did not change mean arterial blood pressure.

    Peptide
    Oxytocin
    Outcome
    No significant changeMean arterial blood pressure
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This was combined with a small but significant net increase in resting diastolic BP, whereas systolic and mean arterial BP or HR as well as baroreflex sensitivity at vasoactive drug challenge were not altered.
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).
  6. 06HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin did not alter heart rate.

    In plain wordsIn healthy men, nasal oxytocin did not change heart rate.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeart rate
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This was combined with a small but significant net increase in resting diastolic BP, whereas systolic and mean arterial BP or HR as well as baroreflex sensitivity at vasoactive drug challenge were not altered.
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).
  7. 07HumanNon-randomized trialEfficacy outcome

    In healthy males, intranasal oxytocin did not alter baroreflex sensitivity at vasoactive drug challenge.

    In plain wordsIn healthy men, nasal oxytocin did not change how the body adjusts blood pressure reflexes.

    Peptide
    Oxytocin
    Outcome
    No significant changeBaroreflex sensitivity at vasoactive drug challenge
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This was combined with a small but significant net increase in resting diastolic BP, whereas systolic and mean arterial BP or HR as well as baroreflex sensitivity at vasoactive drug challenge were not altered.
    1 context sentence
    Summary · context
    In a balanced, double-blind crossover design, oxytocin or placebo was administered intranasally to 12 lean, healthy males (age 25 ± 4 yr).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.