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Study · Other design · 2020

4 results

[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]

Ivko OM, Linkova NS, Ilina AR, Sharova AA, Ryzhak GA

Advances in gerontology = Uspekhi gerontologii1 Jan 2020Cited by 6 (Europe PMC)

PMID33280326 (opens in a new tab)PepBankPUB-33280326
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanOther designEfficacy outcome

    In middle-aged people, the AEDG peptide increased urinary 6-sulfatoxymelatonin excretion 1,7 times.

    In plain wordsIn middle-aged people, the AEDG peptide raised urine levels of a melatonin by-product.

    Peptide
    Epitalon
    Outcome
    IncreaseUrinary 6-sulfatoxymelatonin excretion
    Study

    n: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AEDG peptide increases in 1,7 times the 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people.
  2. 02HumanOther designEfficacy outcome

    In people with reduced melatonin-producing epiphysis function, the AEDG peptide normalized the raised Clock gene expression in leukocytes by 1,9-2,1 times.

    In plain wordsIn people with weaker pineal function, the AEDG peptide brought a raised circadian Clock gene level in white blood cells back toward normal.

    Peptide
    Epitalon
    Outcome
    DecreaseClock gene expression in leukocytes
    Study

    n: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times
    1 context sentence
    Summary · context
    in people with reduced melatonin-producing epiphysis function.
  3. 03HumanOther designEfficacy outcome

    In people with reduced melatonin-producing epiphysis function, the AEDG peptide normalized the raised Csnk1e gene expression in leukocytes by 1,9-2,1 times.

    In plain wordsIn people with weaker pineal function, the AEDG peptide brought a raised circadian Csnk1e gene level in white blood cells back toward normal.

    Peptide
    Epitalon
    Outcome
    DecreaseCsnk1e gene expression in leukocytes
    Study

    n: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times
    1 context sentence
    Summary · context
    in people with reduced melatonin-producing epiphysis function.
  4. 04HumanOther designEfficacy outcome

    In people with reduced melatonin-producing epiphysis function, the AEDG peptide increased the low Cry2 gene expression in peripheral blood lymphocytes 2 times.

    In plain wordsIn people with weaker pineal function, the AEDG peptide raised a low circadian Cry2 gene level in blood lymphocytes.

    Peptide
    Epitalon
    Outcome
    IncreaseCry2 gene expression in lymphocytes
    Study

    n: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and increases the Cry2 gene hypo expression in peripheral blood lymphocytes in 2 times in people with reduced melatonin-producing epiphysis function.
    1 context sentence
    Summary · context
    in people with reduced melatonin-producing epiphysis function.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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