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Study · Animal study (in vivo) · rat · 2021

2 results

Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury.

El-Sisi AEE, Sokar SS, Shebl AM, Mohamed DZ, Abu-Risha SE

Toxicology and applied pharmacology29 Nov 2020Cited by 76 (Europe PMC)

PMID33264646 (opens in a new tab)DOI10.1016/j.taap.2020.115340 (opens in a new tab)PepBankPUB-33264646
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with hepatic ischemia/reperfusion injury, octreotide ameliorated injury measures and augmented antioxidant and anti-apoptotic markers versus HIR controls.

    In plain wordsIn rats, octreotide improved injury measures and protective markers compared with HIR controls.

    Peptide
    Octreotide
    Outcome
    MixedInjury and protective markers
    Study

    ratn: not reported in source

    hepatic ischemia/reperfusion injury
    Comparator
    HIR group
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    50 or 75 μg/kgAs given in this study (rat).

    Source sentences

    Summary
    OCT pretreatment at doses (50 or 75 μg/kg), MLT alone, and MLT + OCT75 significantly ameliorated the biochemical with histopathological changes, oxidative stress, inflammation, apoptosis, then augmented anti-oxidant and anti-apoptotic markers
    3 context sentences
    Summary · context
    compared with HIR group.
    Summary · context
    Rats were randomized into sham, HIR, OCT (50, 75, and 100 µg/kg), MLT, and MLT + OCT75 groups.
    Summary · context
    Ischemia was induced via occlusion of the portal triad for 30 min followed by 24 h reperfusion.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with hepatic ischemia/reperfusion injury, octreotide reduced the listed inflammatory and pyroptosis pathway markers versus HIR controls.

    In plain wordsIn rats, octreotide reduced the listed inflammatory and pyroptosis pathway markers compared with HIR controls.

    Peptide
    Octreotide
    Outcome
    DecreasePathway marker expression
    Study

    ratn: not reported in source

    hepatic ischemia/reperfusion injury
    Comparator
    HIR group
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    50 or 75 μg/kgAs given in this study (rat).

    Source sentences

    Summary
    through downregulation of HMGB1, TLR4, MyD88, TRAF-6, p-IκBα (S32), p-NF-κBp65 (S536), NLRP3, ASC, caspase-1(p20), and GSDMD-N expressions compared with HIR group.
    2 context sentences
    Summary · context
    Rats were randomized into sham, HIR, OCT (50, 75, and 100 µg/kg), MLT, and MLT + OCT75 groups.
    Summary · context
    Ischemia was induced via occlusion of the portal triad for 30 min followed by 24 h reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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