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Study · In vitro (cells) · 2020

3 results

Comparison of the Effects of KE and AED Peptides on Functional Activity of Human Skin Fibroblasts during Their Replicative Aging.

Fridman NV, Linkova NS, Kozhevnikova EO, Gutop EO, Khavinson VK

Bulletin of experimental biology and medicine24 Nov 2020Cited by 3 (Europe PMC)

PMID33231794 (opens in a new tab)DOI10.1007/s10517-020-05022-1 (opens in a new tab)PepBankPUB-33231794
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In aging human skin fibroblasts, AED activated sirtuin-1 synthesis.

    In plain wordsIn human skin cells, AED increased sirtuin-1 production during cell aging.

    Peptide
    Cartalax
    Outcome
    IncreaseSirtuin-1 synthesis
    Study

    humann: not reported in source

    human skin fibroblasts during replicative aging
    Outcome group
    Aging markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AED peptide activates the synthesis of sirtuin-1, sirtuin-6, and collagen I in human skin fibroblasts during their replicative aging, which attests to its geroprotective effect.
    1 context sentence
    Summary · context
    We studied the effect of KE and AED peptides on the expression of sirtuin-1, sirtuin-6, collagen I, cytokines (IL-1, TGF-β), and transcription factor NF-κB in human skin fibroblasts during their replicative aging.
  2. 02LabIn vitro (cells)Mechanism

    In aging human skin fibroblasts, AED activated sirtuin-6 synthesis.

    In plain wordsIn human skin cells, AED increased sirtuin-6 production during cell aging.

    Peptide
    Cartalax
    Outcome
    IncreaseSirtuin-6 synthesis
    Study

    humann: not reported in source

    human skin fibroblasts during replicative aging
    Outcome group
    Aging markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AED peptide activates the synthesis of sirtuin-1, sirtuin-6, and collagen I in human skin fibroblasts during their replicative aging, which attests to its geroprotective effect.
    1 context sentence
    Summary · context
    We studied the effect of KE and AED peptides on the expression of sirtuin-1, sirtuin-6, collagen I, cytokines (IL-1, TGF-β), and transcription factor NF-κB in human skin fibroblasts during their replicative aging.
  3. 03LabIn vitro (cells)Mechanism

    In aging human skin fibroblasts, AED activated collagen I synthesis.

    In plain wordsIn human skin cells, AED increased collagen I production during cell aging.

    Peptide
    Cartalax
    Outcome
    IncreaseCollagen I synthesis
    Study

    humann: not reported in source

    human skin fibroblasts during replicative aging
    Outcome group
    Aging markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AED peptide activates the synthesis of sirtuin-1, sirtuin-6, and collagen I in human skin fibroblasts during their replicative aging, which attests to its geroprotective effect.
    1 context sentence
    Summary · context
    We studied the effect of KE and AED peptides on the expression of sirtuin-1, sirtuin-6, collagen I, cytokines (IL-1, TGF-β), and transcription factor NF-κB in human skin fibroblasts during their replicative aging.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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