Cerebrolysin enhances spinal cord conduction and reduces blood-spinal cord barrier breakdown, edema formation, immediate early gene expression and cord pathology after injury.

Sahib S, Sharma A, Menon PK, Muresanu DF, Castellani RJ, Nozari A, Lafuente JV, Bryukhovetskiy I, Tian ZR, Patnaik R, Buzoianu AD, Wiklund L, Sharma HS

Progress in brain research12 Nov 2020Cited by 15 (Europe PMC)

PMID33223040DOI10.1016/bs.pbr.2020.09.012PepBankPUB-33223040

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, Cerebrolysin pretreatment prevented MNP amplitude loss and increased amplitude above the pre-injury level.
In plain wordsIn rats with spinal cord injury, Cerebrolysin pretreatment preserved signal amplitude and increased it above the pre-injury level.
Peptide
Cerebrolysin
Outcome
IncreaseMNP amplitude with CBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Comparator
Pre-injury level
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
1 context sentence(design, population, supporting numbers)
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, Cerebrolysin pretreatment did not affect SCEP latencies.
In plain wordsIn rats with spinal cord injury, Cerebrolysin pretreatment did not affect spinal signal latencies.
Peptide
Cerebrolysin
Outcome
No significant changeSCEP latencies with CBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
1 context sentence(design, population, supporting numbers)
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304003
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, Cerebrolysin pretreatment significantly reduced edema at the reported assessment.
In plain wordsIn rats with spinal cord injury, Cerebrolysin pretreatment significantly reduced swelling.
Peptide
Cerebrolysin
Outcome
DecreaseEdema with CBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
At 5h, SCI induced edema, BSCB breakdown, and cell injuries were significantly reduced by CBL and NWCBL pretreatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304005
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, Cerebrolysin pretreatment significantly reduced blood-spinal cord barrier breakdown.
In plain wordsIn rats with spinal cord injury, Cerebrolysin pretreatment significantly reduced blood-spinal cord barrier damage.
Peptide
Cerebrolysin
Outcome
DecreaseBlood-spinal cord barrier breakdown with CBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
At 5h, SCI induced edema, BSCB breakdown, and cell injuries were significantly reduced by CBL and NWCBL pretreatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304007
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, Cerebrolysin pretreatment significantly reduced cell injuries.
In plain wordsIn rats with spinal cord injury, Cerebrolysin pretreatment significantly reduced cell injuries.
Peptide
Cerebrolysin
Outcome
DecreaseCell injuries with CBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
At 5h, SCI induced edema, BSCB breakdown, and cell injuries were significantly reduced by CBL and NWCBL pretreatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304009
06AnimalAnimal study (in vivo)Mechanism
In rats with spinal cord injury, Cerebrolysin considerably reduced c-fos expression compared with untreated injury.
In plain wordsIn rats with spinal cord injury, Cerebrolysin reduced c-fos expression compared with untreated injury.
Peptide
Cerebrolysin
Outcome
Decreasec-fos expression with CBL
Study
ratn: not reported in source
Spinal cord injury
Comparator
Untreated spinal cord injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Moreover, expressions of c-fos and c-jun genes that are prominent at 5h in untreated SCI are also considerably reduced by CBL and NWCBL treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304013
07AnimalAnimal study (in vivo)Mechanism
In rats with spinal cord injury, Cerebrolysin considerably reduced c-jun expression compared with untreated injury.
In plain wordsIn rats with spinal cord injury, Cerebrolysin reduced c-jun expression compared with untreated injury.
Peptide
Cerebrolysin
Outcome
Decreasec-jun expression with CBL
Study
ratn: not reported in source
Spinal cord injury
Comparator
Untreated spinal cord injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
5mL/kg · intravenousAs given in this study (rat).
Source sentences
Summary
Moreover, expressions of c-fos and c-jun genes that are prominent at 5h in untreated SCI are also considerably reduced by CBL and NWCBL treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
Report a problemFND-3322304015

Studies that did not test the peptide alone10

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin pretreatment prevented MNP amplitude loss and increased amplitude above the pre-injury level.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin pretreatment preserved signal amplitude and increased it above the pre-injury level.
Peptide
Cerebrolysin
Outcome
IncreaseMNP amplitude with NWCBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Comparator
Pre-injury level
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
1 context sentence(design, population, supporting numbers)
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304002
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin pretreatment did not affect SCEP latencies.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin pretreatment did not affect spinal signal latencies.
Peptide
Cerebrolysin
Outcome
No significant changeSCEP latencies with NWCBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
1 context sentence(design, population, supporting numbers)
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304004
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin pretreatment significantly reduced edema at the reported assessment.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin pretreatment significantly reduced swelling.
Peptide
Cerebrolysin
Outcome
DecreaseEdema with NWCBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
At 5h, SCI induced edema, BSCB breakdown, and cell injuries were significantly reduced by CBL and NWCBL pretreatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304006
11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin pretreatment significantly reduced blood-spinal cord barrier breakdown.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin pretreatment significantly reduced blood-spinal cord barrier damage.
Peptide
Cerebrolysin
Outcome
DecreaseBlood-spinal cord barrier breakdown with NWCBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
At 5h, SCI induced edema, BSCB breakdown, and cell injuries were significantly reduced by CBL and NWCBL pretreatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304008
12AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin pretreatment significantly reduced cell injuries.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin pretreatment significantly reduced cell injuries.
Peptide
Cerebrolysin
Outcome
DecreaseCell injuries with NWCBL pretreatment
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
At 5h, SCI induced edema, BSCB breakdown, and cell injuries were significantly reduced by CBL and NWCBL pretreatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304010
13AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin delivered after injury retained a prominent protective effect on SCEP.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin given after injury retained a prominent protective effect on spinal signals.
Peptide
Cerebrolysin
Outcome
IncreaseSCEP effect with post-injury NWCBL
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Interestingly this effect on SCEP and cord pathology was still prominent when the NWCBL was delivered 2min after SCI.
1 context sentence(design, population, supporting numbers)
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304011
14AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, nanowired Cerebrolysin delivered after injury retained a prominent protective effect on cord pathology.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin given after injury retained a prominent protective effect on spinal cord damage.
Peptide
Cerebrolysin
Outcome
DecreaseCord pathology with post-injury NWCBL
Study
ratn: not reported in source
Spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Interestingly this effect on SCEP and cord pathology was still prominent when the NWCBL was delivered 2min after SCI.
1 context sentence(design, population, supporting numbers)
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304012
15AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with spinal cord injury, nanowired Cerebrolysin considerably reduced c-fos expression compared with untreated injury.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin reduced c-fos expression compared with untreated injury.
Peptide
Cerebrolysin
Outcome
Decreasec-fos expression with NWCBL
Study
ratn: not reported in source
Spinal cord injury
Comparator
Untreated spinal cord injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, expressions of c-fos and c-jun genes that are prominent at 5h in untreated SCI are also considerably reduced by CBL and NWCBL treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304014
16AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with spinal cord injury, nanowired Cerebrolysin considerably reduced c-jun expression compared with untreated injury.
In plain wordsIn rats with spinal cord injury, nanowired Cerebrolysin reduced c-jun expression compared with untreated injury.
Peptide
Cerebrolysin
Outcome
Decreasec-jun expression with NWCBL
Study
ratn: not reported in source
Spinal cord injury
Comparator
Untreated spinal cord injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, expressions of c-fos and c-jun genes that are prominent at 5h in untreated SCI are also considerably reduced by CBL and NWCBL treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304016
17AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with spinal cord injury, low-dose nanowired Cerebrolysin had superior neuroprotective effects on spinal signals and cord pathology compared with conventional Cerebrolysin.
In plain wordsIn rats with spinal cord injury, low-dose nanowired Cerebrolysin protected spinal signals and tissue better than conventional Cerebrolysin.
Peptide
Cerebrolysin
Outcome
IncreaseComparative neuroprotection with low-dose nanowired Cerebrolysin
Study
ratn: not reported in source
Spinal cord injury
Comparator
Conventional Cerebrolysin
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Furthermore, NWCBL in low doses has superior neuroprotective effects on SCEP and cord pathology, not reported earlier.
2 context sentences(design, population, supporting numbers)
Summary · context
Pretreatment with either cerebrolysin (CBL 5mL/kg, i.v. 30min before) alone or TiO₂ nanowired delivery of cerebrolysin (NWCBL 2.5mL/kg, i.v.) prevented the loss of MNP amplitude and even enhanced further from the pre-injury level after SCI without affecting latencies.
Summary · context
SCEP is recorded from epidural space over rat spinal cord T9 and T12 segments after peripheral nerves stimulation.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322304017

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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