Concussive head injury exacerbates neuropathology of sleep deprivation: Superior neuroprotection by co-administration of TiO₂-nanowired cerebrolysin, alpha-melanocyte-stimulating hormone, and mesenchymal stem cells.

Sharma A, Muresanu DF, Sahib S, Tian ZR, Castellani RJ, Nozari A, Lafuente JV, Buzoianu AD, Bryukhovetskiy I, Manzhulo I, Patnaik R, Wiklund L, Sharma HS

Progress in brain research2 Nov 2020Cited by 10 (Europe PMC)

PMID33223033DOI10.1016/bs.pbr.2020.09.003PepBankPUB-33223033

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

01AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with sleep deprivation and concussive head injury, alpha-MSH plus mesenchymal stem cells and Cerebrolysin significantly induced neuroprotection.
In plain wordsIn rats with sleep deprivation and head injury, alpha-MSH plus stem cells and Cerebrolysin induced neuroprotection.
Peptide
Cerebrolysin
Outcome
IncreaseNeuroprotection with conventional combination
Study
ratn: not reported in source
Sleep deprivation with concussive head injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Exogenous administration of α-MSH (250μg/kg) together with MSCs (1×10⁶) and cerebrolysin (a balanced composition of several neurotrophic factors and active peptide fragments) (5mL/kg) significantly induced neuroprotection in SD with CHI.
1 context sentence(design, population, supporting numbers)
Summary · context
Furthermore, possible neuroprotective effects of α-MSH, MSCs and neurotrophic factors treatment were explored in a rat model of SD and CHI.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322303301
02AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In rats with sleep deprivation and concussive head injury, nanowired alpha-MSH plus mesenchymal stem cells and Cerebrolysin enhanced neuroprotection.
In plain wordsIn rats with sleep deprivation and head injury, nanowired alpha-MSH plus stem cells and Cerebrolysin enhanced neuroprotection.
Peptide
Cerebrolysin
Outcome
IncreaseNeuroprotection with nanowired combination
Study
ratn: not reported in source
Sleep deprivation with concussive head injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Interestingly, TiO₂ nanowired delivery of α-MSH (100μg), MSCs, and cerebrolysin (2.5mL/kg) induced enhanced neuroprotection with higher levels of α-MSH and BDNF and decreased the TNF-α in SD with CHI.
1 context sentence(design, population, supporting numbers)
Summary · context
Furthermore, possible neuroprotective effects of α-MSH, MSCs and neurotrophic factors treatment were explored in a rat model of SD and CHI.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322303302
03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with sleep deprivation and concussive head injury, nanowired alpha-MSH plus mesenchymal stem cells and Cerebrolysin produced higher alpha-MSH levels.
In plain wordsIn rats with sleep deprivation and head injury, nanowired alpha-MSH, stem cells, and Cerebrolysin increased alpha-MSH levels.
Peptide
Cerebrolysin
Outcome
IncreaseAlpha-MSH levels with nanowired combination
Study
ratn: not reported in source
Sleep deprivation with concussive head injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Interestingly, TiO₂ nanowired delivery of α-MSH (100μg), MSCs, and cerebrolysin (2.5mL/kg) induced enhanced neuroprotection with higher levels of α-MSH and BDNF and decreased the TNF-α in SD with CHI.
1 context sentence(design, population, supporting numbers)
Summary · context
Furthermore, possible neuroprotective effects of α-MSH, MSCs and neurotrophic factors treatment were explored in a rat model of SD and CHI.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322303303
04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with sleep deprivation and concussive head injury, nanowired alpha-MSH plus mesenchymal stem cells and Cerebrolysin produced higher BDNF levels.
In plain wordsIn rats with sleep deprivation and head injury, nanowired alpha-MSH, stem cells, and Cerebrolysin increased BDNF levels.
Peptide
Cerebrolysin
Outcome
IncreaseBDNF levels with nanowired combination
Study
ratn: not reported in source
Sleep deprivation with concussive head injury
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Interestingly, TiO₂ nanowired delivery of α-MSH (100μg), MSCs, and cerebrolysin (2.5mL/kg) induced enhanced neuroprotection with higher levels of α-MSH and BDNF and decreased the TNF-α in SD with CHI.
1 context sentence(design, population, supporting numbers)
Summary · context
Furthermore, possible neuroprotective effects of α-MSH, MSCs and neurotrophic factors treatment were explored in a rat model of SD and CHI.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322303304
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with sleep deprivation and concussive head injury, nanowired alpha-MSH plus mesenchymal stem cells and Cerebrolysin decreased TNF-alpha.
In plain wordsIn rats with sleep deprivation and head injury, nanowired alpha-MSH, stem cells, and Cerebrolysin decreased TNF-alpha levels.
Peptide
Cerebrolysin
Outcome
DecreaseTNF-alpha with nanowired combination
Study
ratn: not reported in source
Sleep deprivation with concussive head injury
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Interestingly, TiO₂ nanowired delivery of α-MSH (100μg), MSCs, and cerebrolysin (2.5mL/kg) induced enhanced neuroprotection with higher levels of α-MSH and BDNF and decreased the TNF-α in SD with CHI.
1 context sentence(design, population, supporting numbers)
Summary · context
Furthermore, possible neuroprotective effects of α-MSH, MSCs and neurotrophic factors treatment were explored in a rat model of SD and CHI.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3322303305

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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