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Study · Not a test of the peptide alone · 2020

8 results

[The use of neuroprotectors in the treatment of late depression].

Safarova TP, Gavrilova SI

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2020

PMID33205930 (opens in a new tab)DOI10.17116/jnevro202012010246 (opens in a new tab)PepBankPUB-33205930
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 01HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine produced a faster, more pronounced therapeutic response than venlafaxine alone.

    In plain wordsIn older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine produced a faster, greater response than venlafaxine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseTherapeutic response
    Study

    n = 61

    Comparator
    Venlafaxine monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    In the group of patients receiving combined antidepressant therapy, a significantly faster and more pronounced therapeutic response was observed compared to the group of patients treated with antidepressant monotherapy.
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 02HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine reduced depressive symptoms earlier and more than venlafaxine alone.

    In plain wordsIn older patients, pooled combination therapy with Cerebrolysin or carnicetine reduced depressive symptoms earlier and more than venlafaxine alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseDepressive symptoms
    Study

    n = 61

    Comparator
    Venlafaxine monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood

    Measurements

    Earlier depressive symptom reduction
    4 weeks
    Pooled venlafaxine plus cerebrolysin or carnicetine versus venlafaxine monotherapy
    P value for depressive symptom reduction
    < 0.001
    Pooled combination therapy versus venlafaxine monotherapy, by the end of treatment

    Source sentences

    Summary
    In the group of combined therapy, an earlier (by 4 weeks) and significant (p<0.001) reduction of depressive and anxiety symptoms was established by the end of treatment
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  3. 03HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine reduced anxiety symptoms earlier and more than venlafaxine alone.

    In plain wordsIn older patients, pooled combination therapy with Cerebrolysin or carnicetine reduced anxiety symptoms earlier and more than venlafaxine alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAnxiety symptoms
    Study

    n = 61

    Comparator
    Venlafaxine monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood

    Measurements

    Earlier anxiety symptom reduction
    4 weeks
    Pooled venlafaxine plus cerebrolysin or carnicetine versus venlafaxine monotherapy
    P value for anxiety symptom reduction
    < 0.001
    Pooled combination therapy versus venlafaxine monotherapy, by the end of treatment

    Source sentences

    Summary
    In the group of combined therapy, an earlier (by 4 weeks) and significant (p<0.001) reduction of depressive and anxiety symptoms was established by the end of treatment
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  4. 04HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine produced more responders than venlafaxine alone.

    In plain wordsIn older patients with depression, pooled combination therapy with Cerebrolysin or carnicetine produced more responders than venlafaxine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNumber of responders
    Study

    n = 61

    Comparator
    Venlafaxine monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    this group had a significantly higher number of respondents
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  5. 05HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine improved remission quality compared with venlafaxine alone.

    In plain wordsIn older patients with depression, pooled combination therapy with Cerebrolysin or carnicetine improved remission quality compared with venlafaxine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseQuality of therapeutic remission
    Study

    n = 61

    Comparator
    Venlafaxine monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    as well as a better quality of therapeutic remission and a significant improvement in the cognitive functioning of patients compared to the monotherapy group.
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  6. 06HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, pooled venlafaxine plus Cerebrolysin or carnicetine improved cognitive functioning compared with venlafaxine alone.

    In plain wordsIn older patients with depression, pooled combination therapy with Cerebrolysin or carnicetine improved cognition compared with venlafaxine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCognitive functioning
    Study

    n = 61

    Comparator
    Venlafaxine monotherapy
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    as well as a better quality of therapeutic remission and a significant improvement in the cognitive functioning of patients compared to the monotherapy group.
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  7. 07HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, venlafaxine plus Cerebrolysin reduced depressive symptoms less than venlafaxine plus carnicetine at treatment end.

    In plain wordsIn older patients with depression, venlafaxine plus Cerebrolysin reduced depressive symptoms less than venlafaxine plus carnicetine at treatment end.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseDepressive symptom reduction versus carnicetine
    Study

    n: not reported in source

    Comparator
    Venlafaxine plus carnicetine
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    When comparing the effectiveness of different neuroprotectors (cerebrolysin or carnicetine), significant differences in the reduction of depressive and anxiety disorders in favor of carnicetine were established only at the end of the therapeutic course.
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  8. 08HumanNot a test of Cerebrolysin aloneNon-randomized trialEfficacy outcome

    In older patients with depression, venlafaxine plus Cerebrolysin reduced anxiety symptoms less than venlafaxine plus carnicetine at treatment end.

    In plain wordsIn older patients with depression, venlafaxine plus Cerebrolysin reduced anxiety symptoms less than venlafaxine plus carnicetine at treatment end.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAnxiety symptom reduction versus carnicetine
    Study

    n: not reported in source

    Comparator
    Venlafaxine plus carnicetine
    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    When comparing the effectiveness of different neuroprotectors (cerebrolysin or carnicetine), significant differences in the reduction of depressive and anxiety disorders in favor of carnicetine were established only at the end of the therapeutic course.
    2 context sentences
    Summary · context
    The study included 2 groups of patients from the cohort of patients hospitalized in the gerontopsychiatric unit with mild and moderate depression (according to the ICD-10 classification) aged 60 years and older.
    Summary · context
    Both groups received antidepressant monotherapy with venlafaxine (21 people) or combined therapy with the same antidepressant, but in combination with cerebrolysin or carnicetine (40 people) for 8 weeks.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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