In relatives of patients with Alzheimer's disease with mild cognitive dysfunction, Cerebrolysin course therapy had a positive prolonged cognitive effect.
In plain wordsIn relatives with mild cognitive dysfunction, Cerebrolysin treatment had a positive prolonged effect on cognition compared with baseline.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseProlonged cognitive effect in mild cognitive dysfunction
- Study
n = 46
- Comparator
- Baseline
- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- Dose not stated · infusion · four-week courseAs given in this study (human).
Source sentences
A positive prolonged effect of course therapy with cerebrolysin on cognitive functioning of the first degree relatives of patients with AD was established in both groups.
2 context sentences(design, population, supporting numbers)
A cohort of 72 blood relatives of patients with AD, including 46 with objectively confirmed clinical and neuropsychological examination signs of mild cognitive dysfunction (group 1) and 26 (group 2) with cognitive impairment that meets the diagnostic criteria of mild cognitive impairment (ICD-10 F06.7), was studied.
The dynamics of the initial (0 day) indicators of cognitive functioning was compared immediately after a four-week course of treatment with cerebrolysin infusions, as well as 1 and 2 months after its completion, depending on the presence of ApoE4(+) or ApoE4(-) genotype.