Immunohistochemical expression of insulin-like growth factor-1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression.

Stavropoulos A, Varras M, Philippou A, Vasilakaki T, Varra VK, Varra FN, Tsavari A, Lazaris AC, Koutsilieris M

Oncology letters29 Oct 2020Cited by 11 (Europe PMC)

PMID33193855PMCIDPMC7656117DOI10.3892/ol.2020.12258PepBankPUB-33193855

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In endometrial carcinoma, IGF-1Ec expression was higher in non-endometrioid carcinoma than in endometrioid adenocarcinoma.
In plain wordsIn endometrial cancer, serous papillary or clear cell tumours had more of the body's own IGF-1Ec than endometrioid tumours.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIGF-1Ec expression by carcinoma type
Study
n = 99
Comparator
Endometrioid adenocarcinoma
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
In endometrial carcinoma, IGF-1Ec expression was high in non-endometrioid carcinoma (serous papillary or clear cell carcinoma) compared with that in endometrioid adenocarcinoma.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3319385501
02HumanEndogenous levelObservational studyOther
In endometrial carcinoma, IGF-1Ec expression was high in the presence of tumoral necrosis.
In plain wordsIn endometrial cancer, tumours with dead tissue (necrosis) showed high levels of the body's own IGF-1Ec.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIGF-1Ec expression and tumoral necrosis
Study
n = 99
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
IGF-1Ec expression was also high in the presence of tumoral necrosis.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3319385502
03HumanEndogenous levelObservational studyOther
In endometrial carcinoma, IGF-1Ec staining correlated significantly with histological differentiation.
In plain wordsIn endometrial cancer, the body's own IGF-1Ec staining was linked to how developed the tumour cells looked.
Peptide
MGF / PEG-MGF
Outcome
Not applicableIGF-1Ec staining and histological differentiation
Study
n = 99
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
Furthermore, there was a significant correlation between the histological differentiation and the sum of staining intensity and the number of IGF-1Ec immunopositive cells in endometrial carcinoma.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3319385503
04HumanEndogenous levelObservational studyOther
In endometrial carcinoma, IGF-1Ec expression correlated negatively with PTEN expression.
In plain wordsIn endometrial cancer, higher levels of the body's own IGF-1Ec were linked to lower PTEN levels.
Peptide
MGF / PEG-MGF
Outcome
DecreaseIGF-1Ec and PTEN co-expression
Study
n = 99
Outcome group
Cancer biomarkers and prognosis · Cancer
Measurements
Spearman rho
−0.343
IGF-1Ec and PTEN, immunopositive cells
Source sentences
Summary
There was a moderate negative correlation between co-expression of IGF-1Ec and PTEN, for both the number of immunopositive cells (P=0.006, ρ=-0.343) and the sum of staining (scores and intensity; P=0.006, ρ=-0.343).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3319385504
05HumanEndogenous levelObservational studyOther
In endometrial carcinoma, IGF-1Ec expression correlated positively with survivin expression.
In plain wordsIn endometrial cancer, higher levels of the body's own IGF-1Ec were linked to higher survivin levels.
Peptide
MGF / PEG-MGF
Outcome
IncreaseIGF-1Ec and survivin co-expression
Study
n = 99
Outcome group
Cancer biomarkers and prognosis · Cancer
Measurements
Spearman rho
0.225
IGF-1Ec and survivin, sum of staining
Source sentences
Summary
Furthermore, there was a positive correlation between the sum of staining (scores and intensity) and co-expression of IGF-1Ec and survivin (P=0.043, ρ=0.225).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3319385505
06HumanEndogenous levelObservational studyOther
In endometrial carcinoma, IGF-1Ec expression was not associated with p53 expression.
In plain wordsIn endometrial cancer, the body's own IGF-1Ec level was not linked to p53 levels.
Peptide
MGF / PEG-MGF
Outcome
No significant changeIGF-1Ec and p53 co-expression
Study
n = 99
Outcome group
Cancer biomarkers and prognosis · Cancer
Source sentences
Summary
However, there was no association between concomitant expression of IGF-1Ec and p53.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3319385506

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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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