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Study · Animal study (in vivo) · 2020

2 results

Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure.

Kang DH, Choi BY, Lee SH, Kho AR, Jeong JH, Hong DK, Kang BS, Park MK, Song HK, Choi HC, Lim MS, Suh SW

Frontiers in neuroscience16 Oct 2020Cited by 14 (Europe PMC)

PMID33177978 (opens in a new tab)PMCIDPMC7596733 (opens in a new tab)DOI10.3389/fnins.2020.568813 (opens in a new tab)PepBankPUB-33177978
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Summary

Epilepsy is one of the most common and severe brain diseases. The exact cause of epilepsy is unclear. Epilepsy often occurs following brain damage, such as traumatic brain injury (TBI) and ischemia. Cerebrolysin is a porcine brain peptide that is a unique neurotropic and neuroprotective agent. Cerebrolysin has been reported to increase neuroprotective effects after TBI, ischemia, and other CNS diseases. However, the effects of cerebrolysin on seizures are not known. Therefore, this study aimed to investigate the effects of neuropeptide cerebrolysin on neuronal death in the hippocampus after a seizure. To confirm the effects of cerebrolysin, we used a pilocarpine-induced seizure animal model. Cerebrolysin (2.5 ml/kg, i.p., once per day for 7 days) was immediately injected after a seizure induction. After 1 week, we obtained brain tissues and performed staining to histologically evaluate the potentially protective effects of cerebrolysin on seizure-induced neuronal death in the hippocampus. We found that cerebrolysin decreased hippocampal neuronal death after a seizure. In addition, an increase in brain-derived neurotrophic factor (BDNF) was confirmed through Western blot analysis to further support our hypothesis. Therefore, the present study suggests that the administration of cerebrolysin can be a useful therapeutic tool for preventing neuronal death after a seizure.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the seizure animal model, Cerebrolysin decreased hippocampal neuronal death after a seizure.

    In plain wordsIn animals with induced seizures, Cerebrolysin decreased nerve cell death in the hippocampus.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal neuronal death
    Study

    n: not reported in source

    Pilocarpine-induced seizure animal model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 7 daysAs given in this study.

    Source sentences

    Summary
    We found that cerebrolysin decreased hippocampal neuronal death after a seizure.
    2 context sentences
    Summary · context
    To confirm the effects of cerebrolysin, we used a pilocarpine-induced seizure animal model.
    Summary · context
    Cerebrolysin (2.5 ml/kg, i.p., once per day for 7 days) was immediately injected after a seizure induction.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In the seizure animal model, Cerebrolysin treatment increased brain-derived neurotrophic factor measured by Western blot.

    In plain wordsIn animals with induced seizures, Cerebrolysin treatment increased brain-derived neurotrophic factor.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBrain-derived neurotrophic factor
    Study

    n: not reported in source

    Pilocarpine-induced seizure animal model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg · intraperitoneal · 7 daysAs given in this study.

    Source sentences

    Summary
    In addition, an increase in brain-derived neurotrophic factor (BDNF) was confirmed through Western blot analysis to further support our hypothesis.
    2 context sentences
    Summary · context
    To confirm the effects of cerebrolysin, we used a pilocarpine-induced seizure animal model.
    Summary · context
    Cerebrolysin (2.5 ml/kg, i.p., once per day for 7 days) was immediately injected after a seizure induction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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