Skip to content

Study · Animal study (in vivo) · rat · 2020

14 results

The Efficacy of PTH and Abaloparatide to Counteract Immobilization-Induced Osteopenia Is in General Similar.

Brent MB, Thomsen JS, Brüel A

Frontiers in endocrinology9 Oct 2020Cited by 12 (Europe PMC)

PMID33162940 (opens in a new tab)PMCIDPMC7581786 (opens in a new tab)DOI10.3389/fendo.2020.588773 (opens in a new tab)PepBankPUB-33162940
Download PDFPubMedAsk about this study
Jump to 14 results

Summary

Immobilization results in a substantial bone loss and increased fracture risk. Powerful bone anabolic therapies are necessary to counteract the bone loss and reduce fracture risk during periods with immobilization. Intermittent parathyroid hormone 1-34 (PTH) (teriparatide) and PTH related peptide analog abaloparatide (ABL) are potent bone anabolic therapies acting through the same receptor, but induce different durations of signaling response. We investigated the efficacy of PTH or ABL in preventing immobilization-induced bone loss in rats in a direct mole-to-mole comparison. Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature. Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day). Immobilization resulted in a substantial and significant reduction in bone mineral density (aBMD), metaphyseal and epiphyseal trabecular bone volume fraction (BV/TV) and trabecular thickness (Tb.Th), metaphyseal trabecular number (Tb.N), and femoral neck bone strength. Both PTH and ABL prevented the immobilization-induced decrease in aBMD, metaphyseal and epiphyseal Tb.Th, and metaphyseal Tb.N. In addition, PTH rescued the reduction in metaphyseal BV/TV and femoral neck strength, while ABL did not. However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N. In conclusion, in a mole-to-mole comparison the efficacy of PTH and ABL is similar in counteracting immobilization-induced reduction in bone mineral density, deterioration in trabecular microarchitecture, and decrease in bone strength.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide prevented the decrease in areal BMD versus untreated immobilization.

    In plain wordsIn rats, abaloparatide prevented bone density loss compared with untreated immobilization.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseAreal BMD
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    immobilized untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Both PTH and ABL prevented the immobilization-induced decrease in aBMD, metaphyseal and epiphyseal Tb.Th, and metaphyseal Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide prevented the decrease in metaphyseal trabecular thickness versus untreated immobilization.

    In plain wordsIn rats, abaloparatide prevented metaphyseal trabecular thinning compared with untreated immobilization.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMetaphyseal trabecular thickness
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    immobilized untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Both PTH and ABL prevented the immobilization-induced decrease in aBMD, metaphyseal and epiphyseal Tb.Th, and metaphyseal Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide prevented the decrease in epiphyseal trabecular thickness versus untreated immobilization.

    In plain wordsIn rats, abaloparatide prevented epiphyseal trabecular thinning compared with untreated immobilization.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseEpiphyseal trabecular thickness
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    immobilized untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Both PTH and ABL prevented the immobilization-induced decrease in aBMD, metaphyseal and epiphyseal Tb.Th, and metaphyseal Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide prevented the decrease in metaphyseal trabecular number versus untreated immobilization.

    In plain wordsIn rats, abaloparatide preserved metaphyseal trabecular number compared with untreated immobilization.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseMetaphyseal trabecular number
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    immobilized untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    Both PTH and ABL prevented the immobilization-induced decrease in aBMD, metaphyseal and epiphyseal Tb.Th, and metaphyseal Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide did not rescue the reduction in metaphyseal bone volume fraction.

    In plain wordsIn rats, abaloparatide did not reverse the loss of metaphyseal bone volume fraction caused by immobilization.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeMetaphyseal bone volume fraction rescue
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    immobilized untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    In addition, PTH rescued the reduction in metaphyseal BV/TV and femoral neck strength, while ABL did not.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide did not rescue the reduction in femoral neck strength.

    In plain wordsIn rats, abaloparatide did not reverse the loss of femoral neck strength caused by immobilization.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeFemoral neck strength rescue
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    immobilized untreated rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    In addition, PTH rescued the reduction in metaphyseal BV/TV and femoral neck strength, while ABL did not.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in serum calcium effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on serum calcium.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeSerum calcium
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in areal BMD effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on bone density.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeAreal BMD versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in metaphyseal bone volume fraction effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on metaphyseal bone volume fraction.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeMetaphyseal bone volume fraction versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in epiphyseal bone volume fraction effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on epiphyseal bone volume fraction.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeEpiphyseal bone volume fraction versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in metaphyseal trabecular thickness effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on metaphyseal trabecular thickness.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeMetaphyseal trabecular thickness versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in epiphyseal trabecular thickness effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on epiphyseal trabecular thickness.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeEpiphyseal trabecular thickness versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in metaphyseal trabecular number effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on metaphyseal trabecular number.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeMetaphyseal trabecular number versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized rats, abaloparatide and PTH did not differ significantly in epiphyseal trabecular number effects.

    In plain wordsIn rats, abaloparatide and PTH had similar effects on epiphyseal trabecular number.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeEpiphyseal trabecular number versus PTH
    Study

    ratn: not reported in source

    female Wistar rats with BTX-induced immobilization
    Comparator
    PTH
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    77 μg/kg/dayAs given in this study (rat).

    Source sentences

    Summary
    However, the effect of PTH and ABL did not differ significantly for serum calcium, aBMD, metaphyseal, and epiphyseal BV/TV, Tb.Th, or Tb.N.
    2 context sentences
    Summary · context
    Immobilization was achieved by injecting botulinum toxin type A (BTX) into the right hindlimb musculature.
    Summary · context
    Sixty 14-week-old female Wistar rats were allocated to the following groups: Baseline, Control, BTX, BTX + PTH (80 μg/kg/day), and BTX + ABL (77 μg/kg/day).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.