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Study · Randomized controlled trial · 2021

4 results

Intranasal oxytocin decreases self-oriented learning.

Liao Z, Huang L, Luo S

Psychopharmacology6 Nov 2020Cited by 11 (Europe PMC)

PMID33156402 (opens in a new tab)DOI10.1007/s00213-020-05694-7 (opens in a new tab)PepBankPUB-33156402
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In participants in study 1, intranasal oxytocin decreased self-oriented reward learning versus placebo, when self-oriented and prosocial learning were assessed separately.

    In plain wordsIn a study of people given nasal oxytocin or placebo, oxytocin reduced learning from rewards for oneself compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSelf-oriented reward learning (study 1)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In study 1, IN-OT decreased self-oriented reward learning when self-oriented learning and prosocial (other-oriented) learning were assessed separately.
    1 context sentence
    Summary · context
    We performed two double-blind, placebo-controlled studies and used reinforcement learning theory to integrate action and related feedback for participants' behaviors.
  2. 02HumanRandomized controlled trialMechanism

    In study 1, the effect of intranasal oxytocin on self-oriented reward learning was partially due to an oxytocin-related increase in choice variability during self-oriented learning.

    In plain wordsIn a study of people, part of the reduced self-oriented learning with nasal oxytocin came from more varied choices.

    Peptide
    Oxytocin
    Outcome
    IncreaseChoice variability during self-oriented learning
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    These effects were partially due to the OT-related increase in choice variability during self-oriented learning.
    1 context sentence
    Summary · context
    We performed two double-blind, placebo-controlled studies and used reinforcement learning theory to integrate action and related feedback for participants' behaviors.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In study 2, intranasal oxytocin decreased learning performance during self-oriented reward learning when self-related and other-related rewards were present together.

    In plain wordsIn a second study, nasal oxytocin reduced learning performance for self-related rewards compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseLearning performance with self- and other-related rewards together (study 2)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In study 2, IN-OT also decreased learning performance during self-oriented reward learning when self-related and other-related rewards were present together.
    1 context sentence
    Summary · context
    We performed two double-blind, placebo-controlled studies and used reinforcement learning theory to integrate action and related feedback for participants' behaviors.
  4. 04HumanRandomized controlled trialMechanism

    In the two placebo-controlled studies, the effects of intranasal oxytocin on self-oriented learning occurred at an early stage of the learning process and could be moderated by participants' social value orientation.

    In plain wordsIn two placebo-controlled studies, the effect of nasal oxytocin on learning for oneself appeared early and could depend on a person's social value orientation.

    Peptide
    Oxytocin
    Outcome
    Not applicableTiming and moderation of oxytocin effect on self-oriented learning
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    These effects occurred at an early stage of the learning process and could be moderated by the participants' social value orientation.
    1 context sentence
    Summary · context
    We performed two double-blind, placebo-controlled studies and used reinforcement learning theory to integrate action and related feedback for participants' behaviors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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