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Study · In vitro (cells) · 2020

5 results

Cognitive Enhancer Noopept Activates Transcription Factor HIF-1.

Zainullina LF, Ivanova TV, Sadovnikov SV, Vakhitova YV, Seredenin SB

Doklady. Biochemistry and biophysics1 Sept 2020Cited by 6 (Europe PMC)

PMID33119829 (opens in a new tab)DOI10.1134/s1607672920050129 (opens in a new tab)PepBankPUB-33119829
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In SH-SH5Y cells, noopept increased basal HIF-1 DNA-binding activity.

    In plain wordsIn cells, noopept increased basal HIF-1 DNA-binding activity.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseBasal HIF-1 DNA-binding activity
    Study

    n: not reported in source

    SH-SH5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
    1 context sentence
    Summary · context
    The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
  2. 02LabIn vitro (cells)Mechanism

    In SH-SH5Y cells, noopept increased HIF-1 activity induced by hypoxia mimetics.

    In plain wordsIn cells, noopept increased HIF-1 activity induced by substances that mimic low oxygen.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseHypoxia mimetic-induced HIF-1 activity
    Study

    n: not reported in source

    SH-SH5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
    1 context sentence
    Summary · context
    The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
  3. 03LabIn vitro (cells)Mechanism

    In SH-SH5Y cells, reporter data indirectly indicated that noopept inhibited HIF-1 prolyl hydroxylase during HIF1α stabilization.

    In plain wordsIn cells, reporter data indirectly suggested that noopept inhibited HIF-1 prolyl hydroxylase.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseHIF-1 prolyl hydroxylase inhibition
    Study

    n: not reported in source

    SH-SH5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mechanism of stabilization of the oxygen-sensitive HIF1α subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1α protein.
    1 context sentence
    Summary · context
    The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
  4. 04LabIn vitro (cells)Mechanism

    In SH-SH5Y cells, noopept had a positive effect on HIF1α protein levels.

    In plain wordsIn cells, noopept increased HIF1α protein levels.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseHIF1α protein level
    Study

    n: not reported in source

    SH-SH5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mechanism of stabilization of the oxygen-sensitive HIF1α subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1α protein.
    1 context sentence
    Summary · context
    The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
  5. 05LabIn vitro (cells)Mechanism

    In SH-SH5Y cells, noopept altered expression of HIF-1-controlled genes in different metabolic pathways.

    In plain wordsIn cells, noopept changed expression of genes controlled by HIF-1 in different metabolic pathways.

    Peptide
    Noopept (omberacetam)
    Outcome
    Direction not reportedHIF-1-controlled metabolic gene expression
    Study

    n: not reported in source

    SH-SH5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.
    1 context sentence
    Summary · context
    The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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