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Study · Animal study (in vivo) · mouse · 2020

13 results

Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in mice.

Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Zhang YY, Wang YD, Tian FM, Zhang L

Bone & joint research16 Oct 2020Cited by 27 (Europe PMC)

PMID33101657 (opens in a new tab)PMCIDPMC7563035 (opens in a new tab)DOI10.1302/2046-3758.910.bjr-2020-0018.r1 (opens in a new tab)PepBankPUB-33101657
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, PTH(1-34) prevented enhanced cartilage matrix catabolism, with no significant difference between doses.

    In plain wordsIn mice with osteoarthritis, PTH prevented increased cartilage breakdown compared with the disease model, with no significant difference between doses.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseCartilage matrix catabolism
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis model
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    All of these changes were prevented by PTH (1-34) treatment, with no significant difference between the low-dose and high-dose groups.
    3 context sentences
    Summary · context
    Enhanced matrix catabolism, increased apoptosis of chondrocytes in cartilage, and overexpressed JAK2/STAT3 and p-JAK2/p-STAT3 were observed in cartilage in this model.
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, PTH(1-34) prevented increased chondrocyte apoptosis, with no significant difference between doses.

    In plain wordsIn mice with osteoarthritis, PTH prevented increased cartilage cell death compared with the disease model, with no significant difference between doses.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseChondrocyte apoptosis
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis model
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    All of these changes were prevented by PTH (1-34) treatment, with no significant difference between the low-dose and high-dose groups.
    3 context sentences
    Summary · context
    Enhanced matrix catabolism, increased apoptosis of chondrocytes in cartilage, and overexpressed JAK2/STAT3 and p-JAK2/p-STAT3 were observed in cartilage in this model.
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with collagenase-induced osteoarthritis, PTH(1-34) prevented JAK2/STAT3 overexpression in cartilage, with no significant difference between doses.

    In plain wordsIn mice with osteoarthritis, PTH prevented excess cartilage JAK2/STAT3 expression compared with the disease model, with no significant difference between doses.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseJAK2/STAT3 expression
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis model
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    All of these changes were prevented by PTH (1-34) treatment, with no significant difference between the low-dose and high-dose groups.
    3 context sentences
    Summary · context
    Enhanced matrix catabolism, increased apoptosis of chondrocytes in cartilage, and overexpressed JAK2/STAT3 and p-JAK2/p-STAT3 were observed in cartilage in this model.
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with collagenase-induced osteoarthritis, PTH(1-34) prevented p-JAK2/p-STAT3 overexpression, with no significant difference between doses.

    In plain wordsIn mice with osteoarthritis, PTH prevented excess p-JAK2/p-STAT3 expression compared with the disease model, with no significant difference between doses.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Decreasep-JAK2/p-STAT3 expression
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis model
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 or 40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    All of these changes were prevented by PTH (1-34) treatment, with no significant difference between the low-dose and high-dose groups.
    3 context sentences
    Summary · context
    Enhanced matrix catabolism, increased apoptosis of chondrocytes in cartilage, and overexpressed JAK2/STAT3 and p-JAK2/p-STAT3 were observed in cartilage in this model.
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, low-dose PTH increased subchondral bone mineral density compared with the osteoarthritis group.

    In plain wordsIn mice with osteoarthritis, low-dose PTH produced higher subchondral bone density than the untreated disease group.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral bone mineral density
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    2 context sentences
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, high-dose PTH increased subchondral bone mineral density compared with the osteoarthritis group.

    In plain wordsIn mice with osteoarthritis, high-dose PTH produced higher subchondral bone density than the untreated disease group.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral bone mineral density
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    2 context sentences
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, high-dose PTH produced higher subchondral bone mineral density than low-dose PTH.

    In plain wordsIn mice with osteoarthritis, high-dose PTH produced higher subchondral bone density than low-dose PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral bone mineral density
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    PTH 10 μg group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    but these parameters were significantly higher in the PTH 40 μg group than in the PTH 10 μg group.
    3 context sentences
    Summary · context
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, low-dose PTH increased subchondral bone volume/trabecular volume compared with the osteoarthritis group.

    In plain wordsIn mice with osteoarthritis, low-dose PTH produced a higher subchondral bone volume fraction than the untreated disease group.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral bone volume/trabecular volume
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    2 context sentences
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, high-dose PTH increased subchondral bone volume/trabecular volume compared with the osteoarthritis group.

    In plain wordsIn mice with osteoarthritis, high-dose PTH produced a higher subchondral bone volume fraction than the untreated disease group.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral bone volume/trabecular volume
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    2 context sentences
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, high-dose PTH produced higher subchondral bone volume/trabecular volume than low-dose PTH.

    In plain wordsIn mice with osteoarthritis, high-dose PTH produced a higher subchondral bone volume fraction than low-dose PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral bone volume/trabecular volume
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    PTH 10 μg group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    but these parameters were significantly higher in the PTH 40 μg group than in the PTH 10 μg group.
    3 context sentences
    Summary · context
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, low-dose PTH increased subchondral trabecular thickness compared with the osteoarthritis group.

    In plain wordsIn mice with osteoarthritis, low-dose PTH produced thicker subchondral trabeculae than the untreated disease group.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral trabecular thickness
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    2 context sentences
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, high-dose PTH increased subchondral trabecular thickness compared with the osteoarthritis group.

    In plain wordsIn mice with osteoarthritis, high-dose PTH produced thicker subchondral trabeculae than the untreated disease group.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral trabecular thickness
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    Osteoarthritis group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    2 context sentences
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagenase-induced osteoarthritis, high-dose PTH produced greater subchondral trabecular thickness than low-dose PTH.

    In plain wordsIn mice with osteoarthritis, high-dose PTH produced thicker subchondral trabeculae than low-dose PTH.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral trabecular thickness
    Study

    mousen: not reported in source

    Collagenase-induced osteoarthritis in C57Bl/6 mice
    Comparator
    PTH 10 μg group
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/day · six weeksAs given in this study (mouse).

    Source sentences

    Summary
    but these parameters were significantly higher in the PTH 40 μg group than in the PTH 10 μg group.
    3 context sentences
    Summary · context
    Micro-CT analysis indicated that bone mineral density (BMD), bone volume/trabecular volume (BV/TV), and trabecular thickness (Tb.Th) levels were significantly lower in the OA group than those in the Sham, PTH 10 μg, and PTH 40 μg groups, but
    Summary · context
    Collagenase-induced OA was established in C57Bl/6 mice.
    Summary · context
    Therapy with PTH (1-34) (10 μg/kg/day or 40 μg/kg/day) was initiated immediately after surgery and continued for six weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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