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Study · Animal study (in vivo) · mouse · 2021

6 results

Thymosin alpha 1 exerts beneficial extrapulmonary effects in cystic fibrosis.

Bellet MM, Borghi M, Pariano M, Renga G, Stincardini C, D'Onofrio F, Brancorsini S, Garaci E, Costantini C, Romani L

European journal of medicinal chemistry9 Oct 2020Cited by 4 (Europe PMC)

PMID33071052 (opens in a new tab)DOI10.1016/j.ejmech.2020.112921 (opens in a new tab)PepBankPUB-33071052
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cystic fibrosis mice with gut inflammation, Tα1 restored barrier integrity in the gut.

    In plain wordsIn mice with cystic fibrosis and gut inflammation, thymosin alpha‑1 restored the gut barrier.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseGut barrier integrity in CF mice
    Study

    mousen: not reported in source

    mouse model of gut inflammation in cystic fibrosis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, Tα1 restored barrier integrity and immune homeostasis in the inflamed gut of CF mice as well as in mice with the metabolic syndrome, a disorder that may arise in CF patients with high caloric intake despite pancreatic sufficiency.
    1 context sentence
    Summary · context
    In the present study, by resorting to murine models of gut inflammation with clinical relevance for CF patients, we demonstrate that Tα1 can also have beneficial effects in extrapulmonary pathology.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cystic fibrosis mice with gut inflammation, Tα1 restored immune homeostasis in the gut.

    In plain wordsIn mice with cystic fibrosis and gut inflammation, thymosin alpha‑1 restored the gut immune balance.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedGut immune homeostasis in CF mice
    Study

    mousen: not reported in source

    mouse model of gut inflammation in cystic fibrosis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, Tα1 restored barrier integrity and immune homeostasis in the inflamed gut of CF mice as well as in mice with the metabolic syndrome, a disorder that may arise in CF patients with high caloric intake despite pancreatic sufficiency.
    1 context sentence
    Summary · context
    In the present study, by resorting to murine models of gut inflammation with clinical relevance for CF patients, we demonstrate that Tα1 can also have beneficial effects in extrapulmonary pathology.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with metabolic syndrome and gut inflammation, Tα1 restored barrier integrity in the gut.

    In plain wordsIn mice with metabolic syndrome and gut inflammation, thymosin alpha‑1 restored the gut barrier.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseGut barrier integrity in mice with metabolic syndrome
    Study

    mousen: not reported in source

    mouse model of metabolic syndrome with gut inflammation
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, Tα1 restored barrier integrity and immune homeostasis in the inflamed gut of CF mice as well as in mice with the metabolic syndrome, a disorder that may arise in CF patients with high caloric intake despite pancreatic sufficiency.
    1 context sentence
    Summary · context
    In the present study, by resorting to murine models of gut inflammation with clinical relevance for CF patients, we demonstrate that Tα1 can also have beneficial effects in extrapulmonary pathology.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with metabolic syndrome and gut inflammation, Tα1 restored immune homeostasis in the gut.

    In plain wordsIn mice with metabolic syndrome and gut inflammation, thymosin alpha‑1 restored the gut immune balance.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedGut immune homeostasis in mice with metabolic syndrome
    Study

    mousen: not reported in source

    mouse model of metabolic syndrome with gut inflammation
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, Tα1 restored barrier integrity and immune homeostasis in the inflamed gut of CF mice as well as in mice with the metabolic syndrome, a disorder that may arise in CF patients with high caloric intake despite pancreatic sufficiency.
    1 context sentence
    Summary · context
    In the present study, by resorting to murine models of gut inflammation with clinical relevance for CF patients, we demonstrate that Tα1 can also have beneficial effects in extrapulmonary pathology.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mouse models of gut inflammation, the protective effects of Tα1 extended to the pancreas.

    In plain wordsIn mice with gut inflammation, thymosin alpha‑1 also protected the pancreas.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedPancreas protection
    Study

    mousen: not reported in source

    mouse models of gut inflammation
    Outcome group
    Inflammation markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protective effects of Tα1 also extended to pancreas and liver, further emphasizing the beneficial effects of Tα1 in extra-pulmonary complications of CF.
    1 context sentence
    Summary · context
    In the present study, by resorting to murine models of gut inflammation with clinical relevance for CF patients, we demonstrate that Tα1 can also have beneficial effects in extrapulmonary pathology.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mouse models of gut inflammation, the protective effects of Tα1 extended to the liver.

    In plain wordsIn mice with gut inflammation, thymosin alpha‑1 also protected the liver.

    Peptide
    Thymosin alpha-1
    Outcome
    Direction not reportedLiver protection
    Study

    mousen: not reported in source

    mouse models of gut inflammation
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protective effects of Tα1 also extended to pancreas and liver, further emphasizing the beneficial effects of Tα1 in extra-pulmonary complications of CF.
    1 context sentence
    Summary · context
    In the present study, by resorting to murine models of gut inflammation with clinical relevance for CF patients, we demonstrate that Tα1 can also have beneficial effects in extrapulmonary pathology.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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