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Study · Animal study (in vivo) · rat · 2020

10 results

Hydrogels based on low-methoxyl amidated citrus pectin and flaxseed gum formulated with tripeptide glycyl-l-histidyl-l-lysine improve the healing of experimental cutting wounds in rats.

Synytsya A, Poučková P, Zadinová M, Troshchynska Y, Štětina J, Synytsya A, Saloň I, Král V

International journal of biological macromolecules6 Oct 2020Cited by 30 (Europe PMC)

PMID33031852 (opens in a new tab)DOI10.1016/j.ijbiomac.2020.09.251 (opens in a new tab)PepBankPUB-33031852
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cutting wounds, GHK in hydrogels increased healing degree compared with untreated controls.

    In plain wordsIn rats with cutting wounds, GHK in hydrogels increased healing degree compared with no treatment.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseHealing degree versus untreated controls
    Study

    ratsn: not reported in source

    Experimental cutting wounds
    Comparator
    Untreated control animals
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The tripeptide applied in the hydrogels showed significantly higher healing degree and lower healing time than in the control animals without treatment and when it was applied in an aqueous solution.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cutting wounds, GHK in hydrogels increased healing degree compared with GHK in aqueous solution.

    In plain wordsIn rats with cutting wounds, GHK in hydrogels increased healing degree compared with GHK in water.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseHealing degree versus aqueous solution
    Study

    ratsn: not reported in source

    Experimental cutting wounds
    Comparator
    GHK in aqueous solution
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The tripeptide applied in the hydrogels showed significantly higher healing degree and lower healing time than in the control animals without treatment and when it was applied in an aqueous solution.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cutting wounds, GHK in hydrogels reduced healing time compared with untreated controls.

    In plain wordsIn rats with cutting wounds, GHK in hydrogels reduced healing time compared with no treatment.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseHealing time versus untreated controls
    Study

    ratsn: not reported in source

    Experimental cutting wounds
    Comparator
    Untreated control animals
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The tripeptide applied in the hydrogels showed significantly higher healing degree and lower healing time than in the control animals without treatment and when it was applied in an aqueous solution.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cutting wounds, GHK in hydrogels reduced healing time compared with GHK in aqueous solution.

    In plain wordsIn rats with cutting wounds, GHK in hydrogels reduced healing time compared with GHK in water.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseHealing time versus aqueous solution
    Study

    ratsn: not reported in source

    Experimental cutting wounds
    Comparator
    GHK in aqueous solution
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The tripeptide applied in the hydrogels showed significantly higher healing degree and lower healing time than in the control animals without treatment and when it was applied in an aqueous solution.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cutting wounds, histology showed complete healing only with GHK in flaxseed gum hydrogel.

    In plain wordsIn rats with cutting wounds, complete healing occurred only with GHK in flaxseed gum hydrogel.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseComplete histological healing
    Study

    ratsn: not reported in source

    Experimental cutting wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    According to histological analysis, complete healing was achieved only when using the tripeptide in the flaxseed gum hydrogel.

Studies that did not test the peptide alone5

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  1. 06AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome

    In rats with cutting wounds, hydrogels containing GHK and α-l-arginine were effective in wound healing without a synergistic effect.

    In plain wordsIn rats with cutting wounds, hydrogels containing GHK and α-l-arginine improved healing without synergy.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseCombination wound healing
    Study

    ratsn: not reported in source

    Experimental cutting wounds
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    Despite the absence of a synergistic effect, the mixture of the tripeptide and α-l-arginine in the hydrogels was also quite effective in wound healing.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  2. 07LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Mechanism

    In laboratory hydrogels, GHK bound pectin carboxylic groups through interactions involving C3OH and ring oxygen O5.

    In plain wordsIn lab tests, GHK bound pectin carboxylic groups through interactions involving hydroxyl and ring oxygen groups.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicablePeptide-pectin binding
    Study

    n: not reported in source

    LMA pectin hydrogel
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The cationic tripeptide was found to bind to carboxylic groups in LMA pectin, and the C3OH hydroxyl and ring oxygen O5 are involved in this interaction.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  3. 08LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Other

    In laboratory tests, flaxseed gum hydrogel released healing agents with zero order kinetics, while pectin hydrogel released them very slowly.

    In plain wordsIn lab tests, flaxseed gum hydrogel released healing agents with zero order kinetics, while pectin hydrogel released them very slowly.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    MixedDrug release kinetics
    Study

    n: not reported in source

    Pectin and flaxseed gum hydrogels
    Comparator
    Pectin hydrogel
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The former hydrogel released the drugs very slowly, while the latter hydrogel demonstrated zero order releasing kinetics optimal for drug delivery.
    1 context sentence
    Summary · context
    The pectin hydrogel showed high viscosity and strong elastic properties, while the flaxseed gum hydrogel was characterised as a viscoelastic system of much lower viscosity.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  4. 09LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Other

    In laboratory tests, the flaxseed gum hydrogel had much lower viscosity than the pectin hydrogel.

    In plain wordsIn lab tests, the flaxseed gum hydrogel had much lower viscosity than the pectin hydrogel.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseHydrogel viscosity
    Study

    n: not reported in source

    Pectin and flaxseed gum hydrogels for healing-agent delivery
    Comparator
    Pectin hydrogel
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The pectin hydrogel showed high viscosity and strong elastic properties, while the flaxseed gum hydrogel was characterised as a viscoelastic system of much lower viscosity.
    1 context sentence
    Summary · context
    In this study, hydrogels based on low-methoxyl amidated citrus pectin or flaxseed gum were prepared and used for the transport of these healing agents to the experimental cutting wounds affected by extensive skin damage.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  5. 10LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Other

    In laboratory tests, pectin hydrogel had strong elastic properties, whereas flaxseed gum hydrogel was viscoelastic.

    In plain wordsIn lab tests, pectin hydrogel had strong elastic properties, whereas flaxseed gum hydrogel was viscoelastic.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableHydrogel elastic properties
    Study

    n: not reported in source

    Pectin and flaxseed gum hydrogels for healing-agent delivery
    Comparator
    Flaxseed gum hydrogel
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The pectin hydrogel showed high viscosity and strong elastic properties, while the flaxseed gum hydrogel was characterised as a viscoelastic system of much lower viscosity.
    1 context sentence
    Summary · context
    In this study, hydrogels based on low-methoxyl amidated citrus pectin or flaxseed gum were prepared and used for the transport of these healing agents to the experimental cutting wounds affected by extensive skin damage.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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