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Study · Animal study (in vivo) · 2020

6 results

NTS and VTA oxytocin reduces food motivation and food seeking.

Wald HS, Chandra A, Kalluri A, Ong ZY, Hayes MR, Grill HJ

American journal of physiology. Regulatory, integrative and comparative physiology7 Oct 2020Cited by 33 (Europe PMC)

PMID33026822 (opens in a new tab)PMCIDPMC7792820 (opens in a new tab)DOI10.1152/ajpregu.00201.2020 (opens in a new tab)PepBankPUB-33026822
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In an animal model, oxytocin delivered to the lateral ventricle reduced motivation to work for food.

    In plain wordsIn animals, oxytocin delivered into the brain's lateral ventricle reduced the drive to work for food.

    Peptide
    Oxytocin
    Outcome
    DecreaseMotivation to work for food after lateral ventricle oxytocin
    Study

    n: not reported in source

    Progressive ratio operant schedule and operant reinstatement paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · lateral ventricleAs given in this study.

    Source sentences

    Summary
    OT delivered to the LV, NTS, or VTA reduced 1) motivation to work for food and 2) reinstatement of food-seeking behavior.
    1 context sentence
    Summary · context
    OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In an animal model, oxytocin delivered to the nucleus tractus solitarius reduced motivation to work for food.

    In plain wordsIn animals, oxytocin delivered into a hindbrain area, the nucleus tractus solitarius, reduced the drive to work for food.

    Peptide
    Oxytocin
    Outcome
    DecreaseMotivation to work for food after NTS oxytocin
    Study

    n: not reported in source

    Progressive ratio operant schedule and operant reinstatement paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · nucleus tractus solitariusAs given in this study.

    Source sentences

    Summary
    OT delivered to the LV, NTS, or VTA reduced 1) motivation to work for food and 2) reinstatement of food-seeking behavior.
    1 context sentence
    Summary · context
    OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In an animal model, oxytocin delivered to the ventral tegmental area reduced motivation to work for food.

    In plain wordsIn animals, oxytocin delivered into the ventral tegmental area reduced the drive to work for food.

    Peptide
    Oxytocin
    Outcome
    DecreaseMotivation to work for food after VTA oxytocin
    Study

    n: not reported in source

    Progressive ratio operant schedule and operant reinstatement paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · ventral tegmental areaAs given in this study.

    Source sentences

    Summary
    OT delivered to the LV, NTS, or VTA reduced 1) motivation to work for food and 2) reinstatement of food-seeking behavior.
    1 context sentence
    Summary · context
    OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In an animal model, oxytocin delivered to the lateral ventricle reduced reinstatement of food-seeking behavior.

    In plain wordsIn animals, oxytocin delivered into the brain's lateral ventricle reduced the return of food-seeking behavior.

    Peptide
    Oxytocin
    Outcome
    DecreaseReinstatement of food-seeking after lateral ventricle oxytocin
    Study

    n: not reported in source

    Progressive ratio operant schedule and operant reinstatement paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · lateral ventricleAs given in this study.

    Source sentences

    Summary
    OT delivered to the LV, NTS, or VTA reduced 1) motivation to work for food and 2) reinstatement of food-seeking behavior.
    1 context sentence
    Summary · context
    OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In an animal model, oxytocin delivered to the nucleus tractus solitarius reduced reinstatement of food-seeking behavior.

    In plain wordsIn animals, oxytocin delivered into a hindbrain area, the nucleus tractus solitarius, reduced the return of food-seeking behavior.

    Peptide
    Oxytocin
    Outcome
    DecreaseReinstatement of food-seeking after NTS oxytocin
    Study

    n: not reported in source

    Progressive ratio operant schedule and operant reinstatement paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · nucleus tractus solitariusAs given in this study.

    Source sentences

    Summary
    OT delivered to the LV, NTS, or VTA reduced 1) motivation to work for food and 2) reinstatement of food-seeking behavior.
    1 context sentence
    Summary · context
    OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In an animal model, oxytocin delivered to the ventral tegmental area reduced reinstatement of food-seeking behavior.

    In plain wordsIn animals, oxytocin delivered into the ventral tegmental area reduced the return of food-seeking behavior.

    Peptide
    Oxytocin
    Outcome
    DecreaseReinstatement of food-seeking after VTA oxytocin
    Study

    n: not reported in source

    Progressive ratio operant schedule and operant reinstatement paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · ventral tegmental areaAs given in this study.

    Source sentences

    Summary
    OT delivered to the LV, NTS, or VTA reduced 1) motivation to work for food and 2) reinstatement of food-seeking behavior.
    1 context sentence
    Summary · context
    OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS), or ventral tegmental area (VTA), and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food-seeking behavior, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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