In patients with frontotemporal dementia, intranasal oxytocin alone increased activity in regions of the simulation network and in limbic regions associated with emotional expression processing.
In plain wordsIn people with frontotemporal dementia, nasal oxytocin alone increased brain activity in regions linked to imitation and emotional expression.
- Peptide
- Oxytocin
- Outcome
- IncreaseActivity in simulation network and limbic regions with oxytocin alone
- Study
n = 28
- Comparator
- Placebo
- Outcome group
- Brain and neuronal activity · Nervous system and cognition
- Studied dose
- 72 IU · intranasal · single doseAs given in this study (human).
Source sentences
Oxytocin alone and in combination with instructed mimicry increased activity in regions of the simulation network and in limbic regions associated with emotional expression processing.
1 context sentence(design, population, supporting numbers)
In a placebo-controlled, randomized crossover design, 28 patients with FTD received 72 IU intranasal oxytocin or placebo and then completed an fMRI facial expression mimicry task.